Pomalidomide 4'-alkylC5-acid

Cat. No.: HY-130737 Purity: 98.78%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Pomalidomide 4'-alkylC5-acid (Example 3) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC5-acid can be used in the synthesis of PROTAC.

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Pomalidomide 4'-alkylC5-acid Chemical Structure

CAS No. : 2225940-49-6

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
25 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 370	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Cereblon

Molecular Weight

387.39

Formula

C₁₉H₂₁N₃O₆

CAS No.

2225940-49-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(O)CCCCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (129.07 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5814 mL	12.9069 mL	25.8138 mL
5 mM	0.5163 mL	2.5814 mL	5.1628 mL
10 mM	0.2581 mL	1.2907 mL	2.5814 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Dosage

mg/kg

Animal weight
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Dosing volume
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.78%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (248 KB) HNMR (231 KB) LCMS (123 KB)

Handling Instructions (2659 KB)

References

[1]. Jian Jin, et al. Compositions and methods for treating cdk4/6-mediated cancer. Patent WO2018106870A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5814 mL	12.9069 mL	25.8138 mL	64.5344 mL
	5 mM	0.5163 mL	2.5814 mL	5.1628 mL	12.9069 mL
	10 mM	0.2581 mL	1.2907 mL	2.5814 mL	6.4534 mL
	15 mM	0.1721 mL	0.8605 mL	1.7209 mL	4.3023 mL
	20 mM	0.1291 mL	0.6453 mL	1.2907 mL	3.2267 mL
	25 mM	0.1033 mL	0.5163 mL	1.0326 mL	2.5814 mL
	30 mM	0.0860 mL	0.4302 mL	0.8605 mL	2.1511 mL
	40 mM	0.0645 mL	0.3227 mL	0.6453 mL	1.6134 mL
	50 mM	0.0516 mL	0.2581 mL	0.5163 mL	1.2907 mL
	60 mM	0.0430 mL	0.2151 mL	0.4302 mL	1.0756 mL
	80 mM	0.0323 mL	0.1613 mL	0.3227 mL	0.8067 mL
	100 mM	0.0258 mL	0.1291 mL	0.2581 mL	0.6453 mL