Thalidomide-4-O-C2-NH2 hydrochloride
Based on 1 Customer Validation
Thalidomide-4-O-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
For research use only. We do not sell to patients.
- Purity: 99.37%
- CAS No.: 2341840-99-9
- Formula: C15H16ClN3O5
- Molecular Weight:353.76
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All E3 Ligase Ligand-Linker Conjugates Isoforms
More
Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2341840-99-9
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Appearance Solid
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Molecular Weight 353.76
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Formula C15H16ClN3O5
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Color White to off-white
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SMILES
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCN)=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 125 mg/mL (353.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (644 KB)
- English - EN (644 KB)
- Français - FR (644 KB)
- Deutsch - DE (644 KB)
- Norwegian - NO (644 KB)
- Español - ES (644 KB)
- Swedish - SV (644 KB)
- Italian - IT (644 KB)
- Korean - KR (644 KB)
- Portuguese - PT (644 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8268 mL | 14.1338 mL | 28.2676 mL | 70.6690 mL |
| 5 mM | 0.5654 mL | 2.8268 mL | 5.6535 mL | 14.1338 mL | |
| 10 mM | 0.2827 mL | 1.4134 mL | 2.8268 mL | 7.0669 mL | |
| 15 mM | 0.1885 mL | 0.9423 mL | 1.8845 mL | 4.7113 mL | |
| 20 mM | 0.1413 mL | 0.7067 mL | 1.4134 mL | 3.5334 mL | |
| 25 mM | 0.1131 mL | 0.5654 mL | 1.1307 mL | 2.8268 mL | |
| 30 mM | 0.0942 mL | 0.4711 mL | 0.9423 mL | 2.3556 mL | |
| 40 mM | 0.0707 mL | 0.3533 mL | 0.7067 mL | 1.7667 mL | |
| 50 mM | 0.0565 mL | 0.2827 mL | 0.5654 mL | 1.4134 mL | |
| 60 mM | 0.0471 mL | 0.2356 mL | 0.4711 mL | 1.1778 mL | |
| 80 mM | 0.0353 mL | 0.1767 mL | 0.3533 mL | 0.8834 mL | |
| 100 mM | 0.0283 mL | 0.1413 mL | 0.2827 mL | 0.7067 mL |
Thalidomide-4-O-C2-NH2 hydrochloride Related Classifications
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