2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride

Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride 

Cat. No.: HY-112617B
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Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker, can be an immunomodulater for the treatment of cancer.

For research use only. We do not sell to patients.

Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride Chemical Structure

Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride Chemical Structure

CAS No. : 2376990-30-4

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25 mg USD 210 In-stock
50 mg USD 357 In-stock
100 mg USD 610 In-stock
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Based on 1 publication(s) in Google Scholar

Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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  • Purity & Documentation

  • References

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Description

Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride incorporates an E3 ligase ligand and a linker, can be an immunomodulater for the treatment of cancer[1].

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride Related Antibodies
Molecular Weight

498.91

Formula

C21H27ClN4O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCOCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-O-amido-PEG2-C2-NH22376990-30-4E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
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