Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride
Based on 1 Customer Validation
Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 2245697-85-0
- Formula: C25H35ClN4O10
- Molecular Weight:587.02
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-112617B
Thalidomide-O-amido-PEG2-C2-NH2 hydrochloride
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HY-122694A
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride
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HY-107440A
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride
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HY-103615
Thalidomide-O-amido-C4-N3
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HY-130639
Thalidomide-NH-C4-NH-Boc
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HY-107440AR
Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride (Standard)
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HY-103615R
Thalidomide-O-amido-C4-N3 (Standard)
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2245697-85-0
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Appearance Oil
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Molecular Weight 587.02
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Formula C25H35ClN4O10
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Color Light yellow to yellow
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SMILES
O=C(NCCOCCOCCOCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL (85.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7035 mL | 8.5176 mL | 17.0352 mL | 42.5880 mL |
| 5 mM | 0.3407 mL | 1.7035 mL | 3.4070 mL | 8.5176 mL | |
| 10 mM | 0.1704 mL | 0.8518 mL | 1.7035 mL | 4.2588 mL | |
| 15 mM | 0.1136 mL | 0.5678 mL | 1.1357 mL | 2.8392 mL | |
| 20 mM | 0.0852 mL | 0.4259 mL | 0.8518 mL | 2.1294 mL | |
| 25 mM | 0.0681 mL | 0.3407 mL | 0.6814 mL | 1.7035 mL | |
| 30 mM | 0.0568 mL | 0.2839 mL | 0.5678 mL | 1.4196 mL | |
| 40 mM | 0.0426 mL | 0.2129 mL | 0.4259 mL | 1.0647 mL | |
| 50 mM | 0.0341 mL | 0.1704 mL | 0.3407 mL | 0.8518 mL | |
| 60 mM | 0.0284 mL | 0.1420 mL | 0.2839 mL | 0.7098 mL | |
| 80 mM | 0.0213 mL | 0.1065 mL | 0.2129 mL | 0.5323 mL |
Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride Related Classifications
HY-122710A Related Classifications
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