1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugates
  3. Thalidomide-O-amido-PEG2-C2-NH2

Thalidomide-O-amido-PEG2-C2-NH2  (Synonyms: Cereblon Ligand-Linker Conjugates 10; E3 Ligase Ligand-Linker Conjugates 24)

Cat. No.: HY-112617
Handling Instructions

Thalidomide-O-amido-PEG2-C2-NH2 incorporates an E3 ligase ligand and a linker, can be an immunomodulater for the research of cancer.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Thalidomide-O-amido-PEG2-C2-NH2 TFA) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Thalidomide-O-amido-PEG2-C2-NH2 Chemical Structure

Thalidomide-O-amido-PEG2-C2-NH2 Chemical Structure

CAS No. : 1957235-74-3

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Other Forms of Thalidomide-O-amido-PEG2-C2-NH2:

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Description

Thalidomide-O-amido-PEG2-C2-NH2 incorporates an E3 ligase ligand and a linker, can be an immunomodulater for the research of cancer.

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

462.45

Formula

C21H26N4O8

CAS No.
SMILES

O=C(NCCOCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Thalidomide-O-amido-PEG2-C2-NH2 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Thalidomide-O-amido-PEG2-C2-NH2
Cat. No.:
HY-112617
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