Thalidomide-O-amido-PEG2-C2-NH2 TFA
Based on 1 Customer Validation
Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.
For research use only. We do not sell to patients.
- Purity: 99.72%
- CAS No.: 1957235-75-4
- Formula: C23H27F3N4O10
- Molecular Weight:576.48
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Thalidomide-O-amido-C4-NH2 TFA
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Thalidomide-O-amido-PEG3-C2-NH2 TFA
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Thalidomide-O-amido-C8-NH2 TFA
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HY-112618A
Thalidomide-O-amido-C6-NH2 TFA
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HY-41549
Pomalidomide-PEG4-Ph-NH2
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HY-103601
(S,R,S)-AHPC-PEG4-N3
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HY-103600
(S,R,S)-AHPC-PEG1-N3
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HY-103602
(S,R,S)-AHPC-PEG3-NH2 hydrochloride
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HY-103603
(S,R,S)-AHPC-PEG2-NH2 hydrochloride
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HY-103615
Thalidomide-O-amido-C4-N3
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HY-21930
Pomalidomide-PEG4-C-COOH
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HY-103604A
(S,R,S)-AHPC-PEG4-NH2
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1957235-75-4
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Appearance Solid
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Molecular Weight 576.48
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Formula C23H27F3N4O10
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Color White to light yellow
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SMILES
O=C(NCCOCCOCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.O=C(O)C(F)(F)F
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Synonyms
Cereblon Ligand-Linker Conjugates 10 TFA; E3 Ligase Ligand-Linker Conjugates 24 TFA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 150 mg/mL (260.20 mM; Need ultrasonic)
DMSO : 100 mg/mL (173.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (4.34 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (4.34 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (173.47 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.7347 mL | 8.6733 mL | 17.3467 mL | 43.3666 mL |
| 5 mM | 0.3469 mL | 1.7347 mL | 3.4693 mL | 8.6733 mL | |
| 10 mM | 0.1735 mL | 0.8673 mL | 1.7347 mL | 4.3367 mL | |
| 15 mM | 0.1156 mL | 0.5782 mL | 1.1564 mL | 2.8911 mL | |
| 20 mM | 0.0867 mL | 0.4337 mL | 0.8673 mL | 2.1683 mL | |
| 25 mM | 0.0694 mL | 0.3469 mL | 0.6939 mL | 1.7347 mL | |
| 30 mM | 0.0578 mL | 0.2891 mL | 0.5782 mL | 1.4456 mL | |
| 40 mM | 0.0434 mL | 0.2168 mL | 0.4337 mL | 1.0842 mL | |
| 50 mM | 0.0347 mL | 0.1735 mL | 0.3469 mL | 0.8673 mL | |
| 60 mM | 0.0289 mL | 0.1446 mL | 0.2891 mL | 0.7228 mL | |
| 80 mM | 0.0217 mL | 0.1084 mL | 0.2168 mL | 0.5421 mL | |
| 100 mM | 0.0173 mL | 0.0867 mL | 0.1735 mL | 0.4337 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Thalidomide-O-amido-PEG2-C2-NH2 TFA Related Classifications
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