Thalidomide-O-amido-C6-NH2 TFA
Based on 1 Customer Validation
Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 99.82%
- CAS No.: 1950635-14-9
- Formula: C23H27F3N4O8
- Molecular Weight:544.48
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-103614
Thalidomide-O-amido-C8-NH2 TFA
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HY-103611
Thalidomide-O-amido-PEG3-C2-NH2 TFA
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HY-103615
Thalidomide-O-amido-C4-N3
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HY-103613
Thalidomide-O-amido-C4-NH2 TFA
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HY-112617A
Thalidomide-O-amido-PEG2-C2-NH2 TFA
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HY-103614R
Thalidomide-O-amido-C8-NH2 TFA (Standard)
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HY-103601
(S,R,S)-AHPC-PEG4-N3
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HY-103600
(S,R,S)-AHPC-PEG1-N3
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HY-103602
(S,R,S)-AHPC-PEG3-NH2 hydrochloride
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HY-103603
(S,R,S)-AHPC-PEG2-NH2 hydrochloride
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HY-103611R
Thalidomide-O-amido-PEG3-C2-NH2 TFA (Standard)
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HY-103604
(S,R,S)-AHPC-PEG4-NH2 hydrochloride
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1950635-14-9
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Appearance Solid
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Molecular Weight 544.48
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Formula C23H27F3N4O8
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Color White to off-white
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SMILES
O=C(NCCCCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.O=C(O)C(F)(F)F
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Synonyms
Cereblon Ligand-Linker Conjugates 11 TFA; E3 Ligase Ligand-Linker Conjugates 25 TFA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (183.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (9.18 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (9.18 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8366 mL | 9.1831 mL | 18.3661 mL | 45.9154 mL |
| 5 mM | 0.3673 mL | 1.8366 mL | 3.6732 mL | 9.1831 mL | |
| 10 mM | 0.1837 mL | 0.9183 mL | 1.8366 mL | 4.5915 mL | |
| 15 mM | 0.1224 mL | 0.6122 mL | 1.2244 mL | 3.0610 mL | |
| 20 mM | 0.0918 mL | 0.4592 mL | 0.9183 mL | 2.2958 mL | |
| 25 mM | 0.0735 mL | 0.3673 mL | 0.7346 mL | 1.8366 mL | |
| 30 mM | 0.0612 mL | 0.3061 mL | 0.6122 mL | 1.5305 mL | |
| 40 mM | 0.0459 mL | 0.2296 mL | 0.4592 mL | 1.1479 mL | |
| 50 mM | 0.0367 mL | 0.1837 mL | 0.3673 mL | 0.9183 mL | |
| 60 mM | 0.0306 mL | 0.1531 mL | 0.3061 mL | 0.7653 mL | |
| 80 mM | 0.0230 mL | 0.1148 mL | 0.2296 mL | 0.5739 mL | |
| 100 mM | 0.0184 mL | 0.0918 mL | 0.1837 mL | 0.4592 mL |
Thalidomide-O-amido-C6-NH2 TFA Related Classifications
HY-112618A Related Classifications
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