1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Thalidomide-O-amido-C4-NH2 (TFA)

Thalidomide-O-amido-C4-NH2 (TFA) (Synonyms: Cereblon Ligand-Linker Conjugates 6 (TFA); E3 ligase Ligand-Linker Conjugates 19 (TFA))

Cat. No.: HY-103613 Purity: 99.74%
Handling Instructions

Thalidomide-O-amido-C4-NH2 TFA (Cereblon Ligand-Linker Conjugates 6 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-O-amido-C4-NH2 (TFA) Chemical Structure

Thalidomide-O-amido-C4-NH2 (TFA) Chemical Structure

CAS No. : 1799711-25-3

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Description

Thalidomide-O-amido-C4-NH2 TFA (Cereblon Ligand-Linker Conjugates 6 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

IC50 & Target[1]

Cereblon

 

Molecular Weight

516.42

Formula

C₂₁H₂₃F₃N₄O₈

CAS No.

1799711-25-3

SMILES

NCCCCNC(COC1=C(C(N2C(CCC3=O)C(N3)=O)=O)C(C2=O)=CC=C1)=O.FC(F)(F)C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 42.86 mg/mL (82.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9364 mL 9.6820 mL 19.3641 mL
5 mM 0.3873 mL 1.9364 mL 3.8728 mL
10 mM 0.1936 mL 0.9682 mL 1.9364 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.84 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.74%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Thalidomide-O-amido-C4-NH2 (TFA)Cereblon Ligand-Linker Conjugates 6E3 ligase Ligand-Linker Conjugates 19E3 Ligase Ligand-Linker ConjugateInhibitorinhibitorinhibit

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Product Name:
Thalidomide-O-amido-C4-NH2 (TFA)
Cat. No.:
HY-103613
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