1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. (S,R,S)-AHPC-PEG4-N3

(S,R,S)-AHPC-PEG4-N3 (Synonyms: VH032-PEG4-N3; VHL Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 4)

Cat. No.: HY-103601 Purity: 98.23%
Handling Instructions

(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-PEG4-N3 Chemical Structure

(S,R,S)-AHPC-PEG4-N3 Chemical Structure

CAS No. : 1797406-81-5

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100 mg USD 550 In-stock
Estimated Time of Arrival: December 31
500 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
1 g USD 3350 In-stock
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2 g USD 4900 In-stock
Estimated Time of Arrival: December 31
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Description

(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.

IC50 & Target[1]

VHL

 

In Vitro

E3 ligase Ligand-Linker Conjugates 4 together with JQ1 triggers the intracellular destruction of BET proteins[1].

Molecular Weight

689.82

Formula

C₃₂H₄₇N₇O₈S

CAS No.

1797406-81-5

SMILES

O=C(N[[email protected]@H](C(C)(C)C)C(N(C[[email protected]](O)C1)[[email protected]@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCOCCN=[N+]=[N-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (72.48 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4497 mL 7.2483 mL 14.4965 mL
5 mM 0.2899 mL 1.4497 mL 2.8993 mL
10 mM 0.1450 mL 0.7248 mL 1.4497 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

(S,R,S)-AHPC-PEG4-N3VH032-PEG4-N3VHL Ligand-Linker Conjugates 5E3 ligase Ligand-Linker Conjugates 4E3 Ligase Ligand-Linker ConjugateInhibitorinhibitorinhibit

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Product Name:
(S,R,S)-AHPC-PEG4-N3
Cat. No.:
HY-103601
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