(S,R,S)-AHPC-PEG4-N3
Based on 2 publication(s) in Google Scholar
(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 99.71%
- CAS No.: 1797406-81-5
- Formula: C32H47N7O8S
- Molecular Weight:689.82
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) (S,R,S)-AHPC-PEG4-N3
MoreAll E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
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VHL |
Chemical Information
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CAS No. 1797406-81-5
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Appearance Liquid
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Molecular Weight 689.82
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Formula C32H47N7O8S
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Color Colorless to off-white
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SMILES
O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCOCCN=[N+]=[N-]
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Synonyms
VH032-PEG4-N3; VHL Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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ACS Nano
A Cyclized Bivalent Aptamer-Based Protein Degrader Targeting Receptor Tyrosine Kinases Overcomes Resistance to Inhibitors in Lung Cancer. [Abstract]2025 Aug 12;19(31):28171-28185. PMID: 40728393 -
Cell Rep Med
Intracellular sclerostin promotes tumor progression and metastasis as a potential therapeutic target in triple-negative breast cancer. [Abstract]2026 May 19;7(5):102763. PMID: 42030934
Solvent & Solubility
H2O : 100 mg/mL (144.97 mM; Need ultrasonic)
DMSO : 50 mg/mL (72.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.4497 mL | 7.2483 mL | 14.4965 mL | 36.2413 mL |
| 5 mM | 0.2899 mL | 1.4497 mL | 2.8993 mL | 7.2483 mL | |
| 10 mM | 0.1450 mL | 0.7248 mL | 1.4497 mL | 3.6241 mL | |
| 15 mM | 0.0966 mL | 0.4832 mL | 0.9664 mL | 2.4161 mL | |
| 20 mM | 0.0725 mL | 0.3624 mL | 0.7248 mL | 1.8121 mL | |
| 25 mM | 0.0580 mL | 0.2899 mL | 0.5799 mL | 1.4497 mL | |
| 30 mM | 0.0483 mL | 0.2416 mL | 0.4832 mL | 1.2080 mL | |
| 40 mM | 0.0362 mL | 0.1812 mL | 0.3624 mL | 0.9060 mL | |
| 50 mM | 0.0290 mL | 0.1450 mL | 0.2899 mL | 0.7248 mL | |
| 60 mM | 0.0242 mL | 0.1208 mL | 0.2416 mL | 0.6040 mL | |
| H2O | 80 mM | 0.0181 mL | 0.0906 mL | 0.1812 mL | 0.4530 mL |
| 100 mM | 0.0145 mL | 0.0725 mL | 0.1450 mL | 0.3624 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(S,R,S)-AHPC-PEG4-N3 Related Classifications
HY-103601 Related Classifications
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