(S,R,S)-AHPC-PEG2-N3
Based on 1 publication(s) in Google Scholar
(S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-N3 can be used for the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 2010159-45-0
- Formula: C28H39N7O6S
- Molecular Weight:601.72
-
Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) (S,R,S)-AHPC-PEG2-N3
MoreAll E3 Ligase Ligand-Linker Conjugates Isoforms
More
Biological Activity
|
VHL |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2010159-45-0
-
Appearance Liquid
-
Molecular Weight 601.72
-
Formula C28H39N7O6S
-
Color Off-white to yellow
-
SMILES
O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCN=[N+]=[N-]
-
Synonyms
VH032-PEG2-N3; VHL Ligand-Linker Conjugates 6; E3 ligase Ligand-Linker Conjugates 13
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Adv Mater
Proteolysis-triggered RNA Interference for Mitochondrial Iron Dyshomeostasis to Activate Antitumor Immunity in Hepatic Carcinoma. [Abstract]2025 Aug 4:e08457. PMID: 40757917
Solvent & Solubility
DMSO : 125 mg/mL (207.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 50 mg/mL (83.10 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 1.6619 mL | 8.3095 mL | 16.6190 mL | 41.5476 mL |
| 5 mM | 0.3324 mL | 1.6619 mL | 3.3238 mL | 8.3095 mL | |
| 10 mM | 0.1662 mL | 0.8310 mL | 1.6619 mL | 4.1548 mL | |
| 15 mM | 0.1108 mL | 0.5540 mL | 1.1079 mL | 2.7698 mL | |
| 20 mM | 0.0831 mL | 0.4155 mL | 0.8310 mL | 2.0774 mL | |
| 25 mM | 0.0665 mL | 0.3324 mL | 0.6648 mL | 1.6619 mL | |
| 30 mM | 0.0554 mL | 0.2770 mL | 0.5540 mL | 1.3849 mL | |
| 40 mM | 0.0415 mL | 0.2077 mL | 0.4155 mL | 1.0387 mL | |
| 50 mM | 0.0332 mL | 0.1662 mL | 0.3324 mL | 0.8310 mL | |
| 60 mM | 0.0277 mL | 0.1385 mL | 0.2770 mL | 0.6925 mL | |
| 80 mM | 0.0208 mL | 0.1039 mL | 0.2077 mL | 0.5193 mL | |
| DMSO | 100 mM | 0.0166 mL | 0.0831 mL | 0.1662 mL | 0.4155 mL |
(S,R,S)-AHPC-PEG2-N3 Related Classifications
HY-103599 Related Classifications
Powered by Bioz