1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Pomalidomide-PEG1-C2-triazole-Me

Pomalidomide-PEG1-C2-triazole-Me (Synonyms: Cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50)

Cat. No.: HY-125843
Handling Instructions

Pomalidomide-PEG1-C2-triazole-Me is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-triazole-Me can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM.

For research use only. We do not sell to patients.

Pomalidomide-PEG1-C2-triazole-Me Chemical Structure

Pomalidomide-PEG1-C2-triazole-Me Chemical Structure

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Description

Pomalidomide-PEG1-C2-triazole-Me is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-triazole-Me can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1].

IC50 & Target[1]

Cereblon

 

Molecular Weight

426.43

Formula

C₂₀H₂₂N₆O₅

SMILES

CC1=CN(CCOCCNC2=CC=CC(C(N3C4CCC(NC4=O)=O)=O)=C2C3=O)N=N1

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
Pomalidomide-PEG1-C2-triazole-Me
Cat. No.:
HY-125843
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