1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Pomalidomide-PEG1-C2-N3

Pomalidomide-PEG1-C2-N3 (Synonyms: Cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50)

Cat. No.: HY-125843 Purity: 99.65%
Handling Instructions

Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM.

For research use only. We do not sell to patients.

Pomalidomide-PEG1-C2-N3 Chemical Structure

Pomalidomide-PEG1-C2-N3 Chemical Structure

CAS No. : 2271036-44-1

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Description

Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1].

IC50 & Target[1]

Cereblon

 

Molecular Weight

386.36

Formula

C₁₇H₁₈N₆O₅

CAS No.

2271036-44-1

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCN=[N+]=[N-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

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Keywords:

Pomalidomide-PEG1-C2-N3Cereblon Ligand-Linker Conjugates 13E3 ligase Ligand-Linker Conjugates 50E3 Ligase Ligand-Linker ConjugateInhibitorinhibitorinhibit

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Pomalidomide-PEG1-C2-N3
Cat. No.:
HY-125843
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