1. PROTAC
    Cell Cycle/DNA Damage
  2. PROTAC
    CDK
  3. CP-10

CP-10 

Cat. No.: HY-125835 Purity: 98.03%
Handling Instructions

CP-10 is a PROTAC with highly selective, specific, and remarkable CDK6 degradation (DC50=2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6.

For research use only. We do not sell to patients.

CP-10 Chemical Structure

CP-10 Chemical Structure

CAS No. : 2366268-80-4

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 1199 In-stock
Estimated Time of Arrival: December 31
5 mg USD 880 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2650 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

CP-10 is a PROTAC with highly selective, specific, and remarkable CDK6 degradation (DC50=2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6[1].

IC50 & Target[1]

CDK6

2.1 nM (DC50)

Cereblon

 

In Vitro

CP-10 induces nearly 72% degradation of CDK6 at 10 nM and 89% at 100 nM in human glioblastoma U251 cells. The degradation of CDK4 induced by CP-10 is far weaker than that of CDK6 (DC50: 50-80 fold)[1].
CP-10 displays a cell inhibition potential in multiple myeloma cell MM.1S (IC50≈10 nM) and mantle cell lymphoma cells (in Mino, IC50≈8 nM)[1].

Molecular Weight

871.94

Formula

C₄₄H₄₉N₁₃O₇

CAS No.

2366268-80-4

SMILES

CC(C(C1=O)=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCOCCNC6=CC=CC(C(N7C8CCC(NC8=O)=O)=O)=C6C7=O)N=N5)CC4)C=N3)N=C2N1C9CCCC9)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (229.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1469 mL 5.7343 mL 11.4687 mL
5 mM 0.2294 mL 1.1469 mL 2.2937 mL
10 mM 0.1147 mL 0.5734 mL 1.1469 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

CP-10CP10CP 10PROTACCDKProteolysis-targeting chimeraCyclin dependent kinaseInhibitorinhibitorinhibit

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CP-10
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HY-125835
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