1. PROTAC
    Cell Cycle/DNA Damage
  2. PROTAC
    CDK
  3. CP-10

CP-10 

Cat. No.: HY-125835
Handling Instructions

CP-10 is a PROTAC with highly selective, specific, and remarkable CDK6 degradation (DC50=2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6.

For research use only. We do not sell to patients.

CP-10 Chemical Structure

CP-10 Chemical Structure

CAS No. : 2366268-80-4

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Description

CP-10 is a PROTAC with highly selective, specific, and remarkable CDK6 degradation (DC50=2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6[1].

IC50 & Target[1]

CDK6

2.1 nM (DC50)

Cereblon

 

In Vitro

CP-10 induces nearly 72% degradation of CDK6 at 10 nM and 89% at 100 nM in human glioblastoma U251 cells. The degradation of CDK4 induced by CP-10 is far weaker than that of CDK6 (DC50: 50-80 fold)[1].
CP-10 displays a cell inhibition potential in multiple myeloma cell MM.1S (IC50≈10 nM) and mantle cell lymphoma cells (in Mino, IC50≈8 nM)[1].

Molecular Weight

871.94

Formula

C₄₄H₄₉N₁₃O₇

CAS No.

2366268-80-4

SMILES

CC(C(C1=O)=C(C)C2=CN=C(NC3=CC=C(N4CCN(CC5=CN(CCOCCNC6=CC=CC(C(N7C8CCC(NC8=O)=O)=O)=C6C7=O)N=N5)CC4)C=N3)N=C2N1C9CCCC9)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CP-10CP10CP 10PROTACCDKProteolysis-targeting chimeraCyclin dependent kinaseInhibitorinhibitorinhibit

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