1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. (S,R,S)-AHPC-PEG4-NH2 hydrochloride

(S,R,S)-AHPC-PEG4-NH2 hydrochloride (Synonyms: VH032-PEG4-NH2 hydrochloride; VHL Ligand-Linker Conjugates 4 hydrochloride; E3 ligase Ligand-Linker Conjugates 7)

Cat. No.: HY-103604 Purity: 98.34%
Handling Instructions

(S,R,S)-AHPC-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-PEG4-NH2 hydrochloride Chemical Structure

(S,R,S)-AHPC-PEG4-NH2 hydrochloride Chemical Structure

CAS No. : 2064292-52-8

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10 mg USD 80 In-stock
Estimated Time of Arrival: December 31
25 mg USD 160 In-stock
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500 mg USD 1950 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

(S,R,S)-AHPC-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.

IC50 & Target[1]

VHL

 

In Vitro

(S,R,S)-AHPC-PEG4-NH2 hydrochloride, extracted from patent US20170008904A1, can be used in the synthesis of compound A1895 in example 3[1].

Molecular Weight

700.29

Formula

C₃₂H₅₀ClN₅O₈S

CAS No.

2064292-52-8

SMILES

O=C(N[[email protected]@H](C(C)(C)C)C(N(C[[email protected]](O)C1)[[email protected]@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCOCCN.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (71.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4280 mL 7.1399 mL 14.2798 mL
5 mM 0.2856 mL 1.4280 mL 2.8560 mL
10 mM 0.1428 mL 0.7140 mL 1.4280 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

(S,R,S)-AHPC-PEG4-NH2VH032-PEG4-NH2VHL Ligand-Linker Conjugates 4E3 ligase Ligand-Linker Conjugates 7E3 Ligase Ligand-Linker ConjugateInhibitorinhibitorinhibit

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Product Name:
(S,R,S)-AHPC-PEG4-NH2 hydrochloride
Cat. No.:
HY-103604
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