(S,R,S)-AHPC-PEG4-NH2 hydrochloride
Based on 2 publication(s) in Google Scholar
(S,R,S)-AHPC-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.
For research use only. We do not sell to patients.
- Purity: 98.17%
- CAS No.: 2064292-52-8
- Formula: C32H50ClN5O8S
- Molecular Weight:700.29
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) (S,R,S)-AHPC-PEG4-NH2 hydrochloride
MoreAll E3 Ligase Ligand-Linker Conjugates Isoforms
More
Biological Activity
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VHL |
(S,R,S)-AHPC-PEG4-NH2 hydrochloride, extracted from patent US20170008904A1, can be used in the synthesis of compound A1895 in example 3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2064292-52-8
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Appearance Solid
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Molecular Weight 700.29
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Formula C32H50ClN5O8S
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Color White to yellow
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SMILES
O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCOCCN.Cl
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Synonyms
VH032-PEG4-NH2 hydrochloride; VHL Ligand-Linker Conjugates 4 hydrochloride; E3 ligase Ligand-Linker Conjugates 7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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ACS Omega
Development of BODIPY FL VH032 as a High-Affinity and Selective von Hippel-Lindau E3 Ligase Fluorescent Probe and Its Application in a Time-Resolved Fluorescence Resonance Energy-Transfer Assay. [Abstract]2020 Dec 29;6(1):680-695. PMID: 33458521 -
Bioconjug Chem
Development of BODIPY FL Thalidomide As a High-Affinity Fluorescent Probe for Cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer Assay. [Abstract]2020 Nov 18;31(11):2564-2575. PMID: 33070611
Solvent & Solubility
H2O : 50 mg/mL (71.40 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.4280 mL | 7.1399 mL | 14.2798 mL | 35.6995 mL |
| 5 mM | 0.2856 mL | 1.4280 mL | 2.8560 mL | 7.1399 mL | |
| 10 mM | 0.1428 mL | 0.7140 mL | 1.4280 mL | 3.5699 mL | |
| 15 mM | 0.0952 mL | 0.4760 mL | 0.9520 mL | 2.3800 mL | |
| 20 mM | 0.0714 mL | 0.3570 mL | 0.7140 mL | 1.7850 mL | |
| 25 mM | 0.0571 mL | 0.2856 mL | 0.5712 mL | 1.4280 mL | |
| 30 mM | 0.0476 mL | 0.2380 mL | 0.4760 mL | 1.1900 mL | |
| 40 mM | 0.0357 mL | 0.1785 mL | 0.3570 mL | 0.8925 mL | |
| 50 mM | 0.0286 mL | 0.1428 mL | 0.2856 mL | 0.7140 mL | |
| 60 mM | 0.0238 mL | 0.1190 mL | 0.2380 mL | 0.5950 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(S,R,S)-AHPC-PEG4-NH2 hydrochloride Related Classifications
HY-103604 Related Classifications
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