1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Pomalidomide-PEG3-azide

Pomalidomide-PEG3-azide 

Cat. No.: HY-137538 Purity: 98.44%
Handling Instructions

Pomalidomide-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

For research use only. We do not sell to patients.

Pomalidomide-PEG3-azide Chemical Structure

Pomalidomide-PEG3-azide Chemical Structure

CAS No. : 2267306-15-8

Size Price Stock Quantity
50 mg USD 400 In-stock
Estimated Time of Arrival: December 31
100 mg USD 650 In-stock
Estimated Time of Arrival: December 31
500 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
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Description

Pomalidomide-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1].

IC50 & Target[1]

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

488.45

Formula

C₂₁H₂₄N₆O₈

CAS No.
SMILES

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCOCCOCCN=[N+]=[N-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (409.46 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0473 mL 10.2365 mL 20.4729 mL
5 mM 0.4095 mL 2.0473 mL 4.0946 mL
10 mM 0.2047 mL 1.0236 mL 2.0473 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (10.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Pomalidomide-PEG3-azideE3 Ligase Ligand-Linker ConjugatePROTACPEGInhibitorinhibitorinhibit

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Product Name:
Pomalidomide-PEG3-azide
Cat. No.:
HY-137538
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