1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. (S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl

(S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl (Synonyms: VHL Ligand-Linker Conjugates 11; E3 ligase Ligand-Linker Conjugates 11)

Cat. No.: HY-103608
Handling Instructions

(S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl Chemical Structure

(S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl Chemical Structure

CAS No. : 1835705-61-7

Size Price Stock
100 mg USD 550 Ask For Quote & Lead Time
500 mg USD 1950 Ask For Quote & Lead Time
1 g USD 3350 Ask For Quote & Lead Time
2 g USD 4900 Ask For Quote & Lead Time

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Description

(S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

IC50 & Target

VHL

 

Molecular Weight

749.44

Formula

C₃₉H₆₁ClN₄O₆S

CAS No.
SMILES

O=C(N[[email protected]@H](C(C)(C)C)C(N(C[[email protected]](O)C1)[[email protected]@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)CCCCCOCCCCCOCCCCCCCl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (133.43 mM)

Ethanol : 50 mg/mL (66.72 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3343 mL 6.6716 mL 13.3433 mL
5 mM 0.2669 mL 1.3343 mL 2.6687 mL
10 mM 0.1334 mL 0.6672 mL 1.3343 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.34 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.34 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

(S,R,S)-AHPC-(C3-​PEG)​2-​C6-​ClVHL Ligand-Linker Conjugates 11 E3 ligase Ligand-Linker Conjugates 11E3 Ligase Ligand-Linker ConjugateInhibitorinhibitorinhibit

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Product Name:
(S,R,S)-AHPC-(C3-​PEG)​2-​C6-​Cl
Cat. No.:
HY-103608
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