1. PROTAC
  2. PROTAC

HaloPROTAC 2 

Cat. No.: HY-112495 Purity: 98.10%
Handling Instructions

HaloPROTAC 2, a chloroalkane-containing PROTAC, induces degradation of HaloTag fusion proteins.

For research use only. We do not sell to patients.

HaloPROTAC 2 Chemical Structure

HaloPROTAC 2 Chemical Structure

CAS No. : 1799506-06-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 646 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

HaloPROTAC 2, a chloroalkane-containing PROTAC, induces degradation of HaloTag fusion proteins.

In Vitro

HaloPROTAC 1 and HaloPROTAC2, containing different linker lengths, are synthesized. Their ability to degrade GFP-HaloTag7, (stably expressed in HEK 293 cells) is tested tby flow cytometry, measuring changes in mean fluorescence intensity. While 24 hour treatment with HaloPROTAC 1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 μM[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2765 mL 6.3824 mL 12.7647 mL
5 mM 0.2553 mL 1.2765 mL 2.5529 mL
10 mM 0.1276 mL 0.6382 mL 1.2765 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

783.41

Formula

C₃₈H₅₉ClN₄O₉S

CAS No.

1799506-06-1

SMILES

O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[[email protected]]3N(C([[email protected]](C(C)(C)C)NC(COCCOCCOCCOCCOCCCCCCCl)=O)=O)C[[email protected]](O)C3

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 98.10%

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Product Name:
HaloPROTAC 2
Cat. No.:
HY-112495
Quantity:

HaloPROTAC 2

Cat. No.: HY-112495