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HaloPROTAC 2 

Cat. No.: HY-112495 Purity: 98.10%
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HaloPROTAC 2, a chloroalkane-containing PROTAC, induces degradation of HaloTag fusion proteins.

For research use only. We do not sell to patients.

HaloPROTAC 2 Chemical Structure

HaloPROTAC 2 Chemical Structure

CAS No. : 1799506-06-1

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5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
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Description

HaloPROTAC 2, a chloroalkane-containing PROTAC, induces degradation of HaloTag fusion proteins.

In Vitro

HaloPROTAC 1 and HaloPROTAC2, containing different linker lengths, are synthesized. Their ability to degrade GFP-HaloTag7, (stably expressed in HEK 293 cells) is tested tby flow cytometry, measuring changes in mean fluorescence intensity. While 24 hour treatment with HaloPROTAC 1 leads to less than 20% degradation, the longer HaloPROTAC2 leads to nearly 70% degradation of GFP-Halotag7 at 2.5 μM[1].

Molecular Weight

783.41

Formula

C₃₈H₅₉ClN₄O₉S

CAS No.

1799506-06-1

SMILES

O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[[email protected]]3N(C([[email protected]](C(C)(C)C)NC(COCCOCCOCCOCCOCCCCCCCl)=O)=O)C[[email protected]](O)C3

Shipping

Room temperature in continental US; may vary elsewhere

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (63.82 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2765 mL 6.3824 mL 12.7647 mL
5 mM 0.2553 mL 1.2765 mL 2.5529 mL
10 mM 0.1276 mL 0.6382 mL 1.2765 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3.75 mg/mL (4.79 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3.75 mg/mL (4.79 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 37.5 mg/mL (47.87 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.10%

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Product Name:
HaloPROTAC 2
Cat. No.:
HY-112495
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