1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugates
  3. VH285-PEG4-C4-Cl

VH285-PEG4-C4-Cl (Synonyms: HaloPROTAC 3)

Cat. No.: HY-111997
Handling Instructions

VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and 16-atom-length linker. The connector of linker is Halogen group. VH285-PEG4-C4-Cl incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. VH285-PEG4-C4-Cl is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM. VH285-PEG4-C4-Cl is able to induce 90 % degradation of GFP-Halotag at 625 nM. VH285-PEG4-C4-Cl binds to VHL with an IC50 of 0.54 μM.

For research use only. We do not sell to patients.

VH285-PEG4-C4-Cl Chemical Structure

VH285-PEG4-C4-Cl Chemical Structure

CAS No. : 1799506-07-2

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Description

VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and 16-atom-length linker. The connector of linker is Halogen group. VH285-PEG4-C4-Cl incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. VH285-PEG4-C4-Cl is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM. VH285-PEG4-C4-Cl is able to induce 90 % degradation of GFP-Halotag at 625 nM. VH285-PEG4-C4-Cl binds to VHL with an IC50 of 0.54 μM[1].

IC50 & Target

VHL

 

In Vitro

Treatment with 500 nM VH285-PEG4-C4-Cl (HaloPROTAC 3) is able to induce nearly complete knockdown of both HaloTag7-ERK1 and HaloTag7-MEK1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

799.42

Formula

C₄₁H₅₅ClN₄O₈S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
VH285-PEG4-C4-Cl
Cat. No.:
HY-111997
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