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Cat. No.: HY-111997R

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VH285-PEG4-C4-Cl (Standard)

Name: VH285-PEG4-C4-Cl (Standard)
Brand: MedChemExpress
SKU: HY-111997R
Availability: PreOrder

(Synonyms: HaloPROTAC 3 (Standard))

VH285-PEG4-C4-Cl (Standard) is the analytical standard of VH285-PEG4-C4-Cl (HY-111997). This product is intended for research and analytical applications. VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and 16-atom-length linker. The connector of linker is Halogen group. VH285-PEG4-C4-Cl incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. VH285-PEG4-C4-Cl is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM. VH285-PEG4-C4-Cl is able to induce 90 % degradation of GFP-Halotag at 625 nM. VH285-PEG4-C4-Cl binds to VHL with an IC₅₀ of 0.54 μM.

For research use only. We do not sell to patients.

CAS No.: 1799506-07-2
Formula: C₄₁H₅₅ClN₄O₈S
Molecular Weight:799.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

VH285-PEG4-C4-Cl (Standard) Chemical Structure

CAS No.: 1799506-07-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1799506-07-2
Molecular Weight 799.42
Formula C₄₁H₅₅ClN₄O₈S
SMILES

CC(N=CS1)=C1C2=CC(OCCOCCOCCOCCCCCCCl)=C(CNC([C@@H]3C[C@@H](O)CN3C([C@@H](N4CC(C=CC=C5)=C5C4=O)C(C)C)=O)=O)C=C2
Synonyms

HaloPROTAC 3 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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