1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Thalidomide-O-PEG2-propargyl

Thalidomide-O-PEG2-propargyl (Synonyms: E3 ligase Ligand-Linker Conjugates 32)

Cat. No.: HY-126458 Purity: 97.57%
Handling Instructions

Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.

For research use only. We do not sell to patients.

Thalidomide-O-PEG2-propargyl Chemical Structure

Thalidomide-O-PEG2-propargyl Chemical Structure

CAS No. : 2098487-52-4

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100 mg USD 350 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology[1].

IC50 & Target[1]

Cereblon

 

Molecular Weight

400.38

Formula

C₂₀H₂₀N₂O₇

CAS No.
SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCCOCCOCC#C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 120 mg/mL (299.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4976 mL 12.4881 mL 24.9763 mL
5 mM 0.4995 mL 2.4976 mL 4.9953 mL
10 mM 0.2498 mL 1.2488 mL 2.4976 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (7.49 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (7.49 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (7.49 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 97.57%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Thalidomide-O-PEG2-propargylE3 ligase Ligand-Linker Conjugates 32E3 Ligase Ligand-Linker ConjugatePROTACInhibitorinhibitorinhibit

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Product Name:
Thalidomide-O-PEG2-propargyl
Cat. No.:
HY-126458
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