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Cat. No.: HY-129941

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(S,R,S)-AHPC-C10-NH2

Name: (S,R,S)-AHPC-C10-NH2
Brand: MedChemExpress
SKU: HY-129941
Availability: PreOrder

(Synonyms: VH032-C10-NH2)

(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC.

For research use only. We do not sell to patients.

CAS No.: 2341796-74-3
Formula: C₃₃H₅₁N₅O₄S
Molecular Weight:613.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

(S,R,S)-AHPC-C10-NH2 Chemical Structure

CAS No.: 2341796-74-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for BET-Targeted PROTAC^[1].

IC₅₀ & Target^[1]

VHL

All E3 Ligase Ligand-Linker Conjugates Isoforms :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2341796-74-3
Molecular Weight 613.85
Formula C₃₃H₅₁N₅O₄S
SMILES

NCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)=O
Synonyms

VH032-C10-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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- In Vitro
Chemical Information
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(S,R,S)-AHPC-C10-NH2

(S,R,S)-AHPC-C8-NH2

(S,R,S)-AHPC-C6-NH2

(S,R,S)-AHPC-Me hydrochloride

(S,R,S)-AHPC-PEG1-N3

(S,R,S)-AHPC-PEG4-NH2 hydrochloride

(S,R,S)-AHPC-PEG3-N3

(S,R,S)-AHPC-C10-NH2 dihydrochloride

(S,R,S)-AHPC-PEG3-NH2 hydrochloride

(S,R,S)-AHPC-PEG2-NH2 hydrochloride

(S,R,S)-AHPC-C3-NH2

(S,R,S)-AHPC-PEG4-NH2

(S,R,S)-AHPC-PEG6-C4-Cl

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

(S,R,S)-AHPC-C10-NH2

(S,R,S)-AHPC-C8-NH2

(S,R,S)-AHPC-C6-NH2

(S,R,S)-AHPC-Me hydrochloride

(S,R,S)-AHPC-PEG1-N3

(S,R,S)-AHPC-PEG4-NH2 hydrochloride

(S,R,S)-AHPC-PEG3-N3

(S,R,S)-AHPC-C10-NH2 dihydrochloride

(S,R,S)-AHPC-PEG3-NH2 hydrochloride

(S,R,S)-AHPC-PEG2-NH2 hydrochloride

(S,R,S)-AHPC-C3-NH2

(S,R,S)-AHPC-PEG4-NH2

(S,R,S)-AHPC-PEG6-C4-Cl

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(S,R,S)-AHPC-C10-NH2 Related Classifications

HY-129941 Related Classifications

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