(S,R,S)-AHPC-C2-NH2
(S,R,S)-AHPC-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology.
For research use only. We do not sell to patients.
- CAS No.: 2241643-69-4
- Formula: C25H35N5O4S
- Molecular Weight:501.64
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
-
HY-136163
(S,R,S)-AHPC-C2-NH2 dihydrochloride
-
HY-133487B
(S,R,S)-AHPC-C8-NH2
-
HY-103600
(S,R,S)-AHPC-PEG1-N3
-
HY-42424
(S,R,S)-AHPC-Me hydrochloride
-
HY-103602
(S,R,S)-AHPC-PEG3-NH2 hydrochloride
-
HY-103603
(S,R,S)-AHPC-PEG2-NH2 hydrochloride
-
HY-103604
(S,R,S)-AHPC-PEG4-NH2 hydrochloride
-
HY-123109
(S,R,S)-AHPC-Boc
-
HY-103606
(S,R,S)-AHPC-PEG6-C4-Cl
-
HY-139345
(S,R,S)-AHPC-CO-C9-acid
-
HY-141016
(S,R,S)-AHPC-PEG2-acid
-
HY-103607
(S,R,S)-AHPC-PEG2-C4-Cl
All E3 Ligase Ligand-Linker Conjugates Isoforms
More
Biological Activity
|
VHL |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2241643-69-4
-
Molecular Weight 501.64
-
Formula C25H35N5O4S
-
SMILES
O=C(N(C[C@@H]1O)[C@@H](C1)C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[C@H](C(C)(C)C)NC(CCN)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. [Content Brief]
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S,R,S)-AHPC-C2-NH2 Related Classifications
HY-136163A Related Classifications
Powered by Bioz