1. PROTAC
  2. Ligand for E3 Ligase
  3. (S,R,S)-AHPC-Boc

(S,R,S)-AHPC-Boc (Synonyms: VH032-Boc)

Cat. No.: HY-123109
Handling Instructions

(S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Boc is used in PROTAC technology.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-Boc Chemical Structure

(S,R,S)-AHPC-Boc Chemical Structure

CAS No. : 1448189-98-7

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Description

(S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Boc is used in PROTAC technology[1].

IC50 & Target[1]

VHL

 

In Vitro

The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional PROTACs to induce ubiquitination and subsequent proteasomal degradation of a target protein.

Molecular Weight

530.68

Formula

C₂₇H₃₈N₄O₅S

CAS No.

1448189-98-7

SMILES

O=C(OC(C)(C)C)N[[email protected]@H](C(C)(C)C)C(N1[[email protected]](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[[email protected]@H](O)C1)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(S,R,S)-AHPC-BocVH032-BocLigand for E3 LigaseE3 ligase-recruiting MoietyubiquitouslyE3ligasecomplexesbifunctionaldegradationligandInhibitorinhibitorinhibit

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(S,R,S)-AHPC-Boc
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