2. PROTAC
  3. Ligands for E3 Ligase
  4. (S,R,S)-AHPC-Boc

(S,R,S)-AHPC-Boc  (Synonyms: VH032-Boc)

Cat. No.: HY-123109 Purity: 95.21%
COA Handling Instructions

(S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Boc is used in PROTAC technology.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-Boc Chemical Structure

(S,R,S)-AHPC-Boc Chemical Structure

CAS No. : 1448189-98-7

Size Price Stock Quantity
Free Sample (0.1 - 0.5 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 330 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 330 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

(S,R,S)-AHPC-Boc (VH032-Boc) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Boc is used in PROTAC technology[1].

IC50 & Target[1]

VHL

 

In Vitro

The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional PROTACs to induce ubiquitination and subsequent proteasomal degradation of a target protein.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

530.68

Appearance

Solid

Formula

C27H38N4O5S
CAS No.
SMILES

O=C(OC(C)(C)C)N[[email protected]@H](C(C)(C)C)C(N1[[email protected]](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[[email protected]@H](O)C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (188.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8844 mL 9.4219 mL 18.8437 mL
5 mM 0.3769 mL 1.8844 mL 3.7687 mL
10 mM 0.1884 mL 0.9422 mL 1.8844 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.71 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.71 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(S,R,S)-AHPC-Boc1448189-98-7VH032-BocLigands for E3 LigaseE3 ligase-recruiting MoietyubiquitouslyE3ligasecomplexesbifunctionaldegradationligandInhibitorinhibitorinhibit

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