(S,R,S)-AHPC-CO-C9-acid
Based on 1 Customer Validation
(S,R,S)-AHPC-CO-C9-acid is an E3 ligase ligand-linker conjugate that can be connected to the ligand for protein to form PROTACs.
For research use only. We do not sell to patients.
- Purity: 95.00%
- CAS No.: 2172819-78-0
- Formula: C33H48N4O6S
- Molecular Weight:628.82
-
Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
HY-130271
(S,R,S)-AHPC-PEG5-COOH
-
HY-148671
(S,R,S)-AHPC-amido-C7-acid
-
HY-130816
(S,R,S)-AHPC-O-Ph-PEG1-NH2
-
HY-125845
(S,R,S)-AHPC
-
HY-126456
(S,R,S)-AHPC-propargyl
-
HY-131168
(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH
-
HY-136055
(S,R,S)-AHPC-C5-COOH
-
HY-114176
(S,R,S)-AHPC-C4-NH2 hydrochloride
-
HY-133487B
(S,R,S)-AHPC-C8-NH2
-
HY-42424
(S,R,S)-AHPC-Me hydrochloride
-
HY-103600
(S,R,S)-AHPC-PEG1-N3
-
HY-103602
(S,R,S)-AHPC-PEG3-NH2 hydrochloride
All E3 Ligase Ligand-Linker Conjugates Isoforms
More
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H69 | IC50 |
>40 μM
Compound: s-4h
|
Antiproliferative activity against human NCI-H69 cells assessed as inhibition of cell proliferation
Antiproliferative activity against human NCI-H69 cells assessed as inhibition of cell proliferation
|
[PMID: 32179332] |
Chemical Information
-
CAS No. 2172819-78-0
-
Appearance Solid
-
Molecular Weight 628.82
-
Formula C33H48N4O6S
-
Color White to off-white
-
SMILES
OC(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O)=O
-
Synonyms
VH032-NH-CO-C9-acid
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (159.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (7.95 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (7.95 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (272 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5903 mL | 7.9514 mL | 15.9028 mL | 39.7570 mL |
| 5 mM | 0.3181 mL | 1.5903 mL | 3.1806 mL | 7.9514 mL | |
| 10 mM | 0.1590 mL | 0.7951 mL | 1.5903 mL | 3.9757 mL | |
| 15 mM | 0.1060 mL | 0.5301 mL | 1.0602 mL | 2.6505 mL | |
| 20 mM | 0.0795 mL | 0.3976 mL | 0.7951 mL | 1.9879 mL | |
| 25 mM | 0.0636 mL | 0.3181 mL | 0.6361 mL | 1.5903 mL | |
| 30 mM | 0.0530 mL | 0.2650 mL | 0.5301 mL | 1.3252 mL | |
| 40 mM | 0.0398 mL | 0.1988 mL | 0.3976 mL | 0.9939 mL | |
| 50 mM | 0.0318 mL | 0.1590 mL | 0.3181 mL | 0.7951 mL | |
| 60 mM | 0.0265 mL | 0.1325 mL | 0.2650 mL | 0.6626 mL | |
| 80 mM | 0.0199 mL | 0.0994 mL | 0.1988 mL | 0.4970 mL | |
| 100 mM | 0.0159 mL | 0.0795 mL | 0.1590 mL | 0.3976 mL |
(S,R,S)-AHPC-CO-C9-acid Related Classifications
HY-139345 Related Classifications
Powered by Bioz