(S,R,S)-AHPC-O-Ph-PEG1-NH2
Based on 1 Customer Validation
(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1 (HY-130614). PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02.
For research use only. We do not sell to patients.
- Purity: 96.97%
- CAS No.: 2361117-24-8
- Formula: C32H41N5O6S
- Molecular Weight:623.76
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-103600
(S,R,S)-AHPC-PEG1-N3
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HY-103602
(S,R,S)-AHPC-PEG3-NH2 hydrochloride
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HY-103603
(S,R,S)-AHPC-PEG2-NH2 hydrochloride
All E3 Ligase Ligand-Linker Conjugates Isoforms
More
Biological Activity
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VHL |
Chemical Information
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CAS No. 2361117-24-8
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Appearance Solid
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Molecular Weight 623.76
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Formula C32H41N5O6S
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Color White to off-white
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SMILES
NCCOC1=CC=C(C=C1)OCC(N[C@H](C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C=C3)C4=C(N=CS4)C)=O)=O)C(C)(C)C)=O
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Synonyms
VH032-O-Ph-PEG1-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (160.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6032 mL | 8.0159 mL | 16.0318 mL | 40.0795 mL |
| 5 mM | 0.3206 mL | 1.6032 mL | 3.2064 mL | 8.0159 mL | |
| 10 mM | 0.1603 mL | 0.8016 mL | 1.6032 mL | 4.0080 mL | |
| 15 mM | 0.1069 mL | 0.5344 mL | 1.0688 mL | 2.6720 mL | |
| 20 mM | 0.0802 mL | 0.4008 mL | 0.8016 mL | 2.0040 mL | |
| 25 mM | 0.0641 mL | 0.3206 mL | 0.6413 mL | 1.6032 mL | |
| 30 mM | 0.0534 mL | 0.2672 mL | 0.5344 mL | 1.3360 mL | |
| 40 mM | 0.0401 mL | 0.2004 mL | 0.4008 mL | 1.0020 mL | |
| 50 mM | 0.0321 mL | 0.1603 mL | 0.3206 mL | 0.8016 mL | |
| 60 mM | 0.0267 mL | 0.1336 mL | 0.2672 mL | 0.6680 mL | |
| 80 mM | 0.0200 mL | 0.1002 mL | 0.2004 mL | 0.5010 mL | |
| 100 mM | 0.0160 mL | 0.0802 mL | 0.1603 mL | 0.4008 mL |
(S,R,S)-AHPC-O-Ph-PEG1-NH2 Related Classifications
HY-130816 Related Classifications
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