1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. (S,R,S)-AHPC-O-Ph-PEG1-NH2

(S,R,S)-AHPC-O-Ph-PEG1-NH2 (Synonyms: VH032-O-Ph-PEG1-NH2)

Cat. No.: HY-130816
Handling Instructions

(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1 (HY-130614). PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-O-Ph-PEG1-NH2 Chemical Structure

(S,R,S)-AHPC-O-Ph-PEG1-NH2 Chemical Structure

CAS No. : 2361117-24-8

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Description

(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1 (HY-130614). PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02[1].

IC50 & Target[1]

VHL

 

Molecular Weight

623.76

Formula

C₃₂H₄₁N₅O₆S

CAS No.

2361117-24-8

SMILES

NCCOC1=CC=C(C=C1)OCC(N[[email protected]](C(N2[[email protected]@H](C[[email protected]](C2)O)C(NCC3=CC=C(C=C3)C4=C(N=CS4)C)=O)=O)C(C)(C)C)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(S,R,S)-AHPC-O-Ph-PEG1-NH2VH032-O-Ph-PEG1-NH2E3 Ligase Ligand-Linker ConjugateEEDpolycombrepressivecomplex 2linkerconjugateInhibitorinhibitorinhibit

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Product Name:
(S,R,S)-AHPC-O-Ph-PEG1-NH2
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HY-130816
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