2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-O-Ph-PEG1-NH2

(S,R,S)-AHPC-O-Ph-PEG1-NH2  (Synonyms: VH032-O-Ph-PEG1-NH2)

Cat. No.: HY-130816 Purity: 96.97%
COA Handling Instructions

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(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1 (HY-130614). PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-O-Ph-PEG1-NH2 Chemical Structure

(S,R,S)-AHPC-O-Ph-PEG1-NH2 Chemical Structure

CAS No. : 2361117-24-8

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25 mg USD 375 In-stock
50 mg USD 605 In-stock
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Based on 1 publication(s) in Google Scholar

(S,R,S)-AHPC-O-Ph-PEG1-NH2 Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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Description

(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1 (HY-130614). PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02[1].

IC50 & Target[1]

VHL

 

Molecular Weight

623.76

Formula

C32H41N5O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NCCOC1=CC=C(C=C1)OCC(N[C@H](C(N2[C@@H](C[C@H](C2)O)C(NCC3=CC=C(C=C3)C4=C(N=CS4)C)=O)=O)C(C)(C)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (160.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6032 mL 8.0159 mL 16.0318 mL
5 mM 0.3206 mL 1.6032 mL 3.2064 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 96.97%

COA (253 KB) HNMR (281 KB) LCMS (266 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6032 mL 8.0159 mL 16.0318 mL 40.0795 mL
5 mM 0.3206 mL 1.6032 mL 3.2064 mL 8.0159 mL
10 mM 0.1603 mL 0.8016 mL 1.6032 mL 4.0080 mL
15 mM 0.1069 mL 0.5344 mL 1.0688 mL 2.6720 mL
20 mM 0.0802 mL 0.4008 mL 0.8016 mL 2.0040 mL
25 mM 0.0641 mL 0.3206 mL 0.6413 mL 1.6032 mL
30 mM 0.0534 mL 0.2672 mL 0.5344 mL 1.3360 mL
40 mM 0.0401 mL 0.2004 mL 0.4008 mL 1.0020 mL
50 mM 0.0321 mL 0.1603 mL 0.3206 mL 0.8016 mL
60 mM 0.0267 mL 0.1336 mL 0.2672 mL 0.6680 mL
80 mM 0.0200 mL 0.1002 mL 0.2004 mL 0.5010 mL
100 mM 0.0160 mL 0.0802 mL 0.1603 mL 0.4008 mL
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(S,R,S)-AHPC-O-Ph-PEG1-NH2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-O-Ph-PEG1-NH22361117-24-8VH032-O-Ph-PEG1-NH2E3 Ligase Ligand-Linker ConjugatesEEDpolycombrepressivecomplex 2linkerconjugateInhibitorinhibitorinhibit

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