1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH

(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (Synonyms: VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH)

Cat. No.: HY-131168
Handling Instructions

(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a E3 ligase ligand-linker conjugate that contains on one end a VHL ligand. (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH is used in PROTAC technology.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH Chemical Structure

(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH Chemical Structure

CAS No. : 2086301-47-3

Size Price Stock Quantity
10 mg USD 800 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2400 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Description

(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a E3 ligase ligand-linker conjugate that contains on one end a VHL ligand. (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH is used in PROTAC technology[1].

IC50 & Target[1]

VHL

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

754.98

Formula

C₃₉H₅₈N₆O₇S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 220 mg/mL (291.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3245 mL 6.6227 mL 13.2454 mL
5 mM 0.2649 mL 1.3245 mL 2.6491 mL
10 mM 0.1325 mL 0.6623 mL 1.3245 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5.5 mg/mL (7.28 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5.5 mg/mL (7.28 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.31 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH
Cat. No.:
HY-131168
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