1. PROTAC
    Metabolic Enzyme/Protease
  2. E3 Ligase Ligand-Linker Conjugate
    HIF/HIF Prolyl-Hydroxylase
  3. (S,R,S)-AHPC-C5-COOH

(S,R,S)-AHPC-C5-COOH (Synonyms: VH032-C5-COOH)

Cat. No.: HY-136055
Handling Instructions

(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-C5-COOH Chemical Structure

(S,R,S)-AHPC-C5-COOH Chemical Structure

CAS No. : 2267282-19-7

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Description

(S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized E3 ligase ligand-linker conjugate, contains the VH032 VHL-based ligand and a linker to form PROTACs. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a Kd of 185 nM, has the potential for the study of anemia and ischemic diseases[1].

IC50 & Target[1]

VHL

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.The von Hippel–Lindau tumor suppressor protein is the substrate-binding subunit of the VHL E3 ubiquitin ligase, it targets hydroxylated α subunit of HIFs for ubiquitination and subsequent proteasomal degradation.

Molecular Weight

558.73

Formula

C₂₉H₄₂N₄O₅S

CAS No.

2267282-19-7

SMILES

O=C(N(C[[email protected]](O)C1)[[email protected]@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)[[email protected]](C(C)(C)C)NCCCCCCC(O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(S,R,S)-AHPC-C5-COOHVH032-C5-COOHE3 Ligase Ligand-Linker ConjugateHIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHCancerVHLHIF-1αPROTACanemiaischemictumorInhibitorinhibitorinhibit

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(S,R,S)-AHPC-C5-COOH
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