1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase

KC7F2 

Cat. No.: HY-18777 Purity: 99.38%
Data Sheet SDS Handling Instructions

KC7F2 is a potent HIF-1 pathway inhibitor and that its potential as a cancer therapy agent warrants further study.

For research use only. We do not sell to patients.
KC7F2 Chemical Structure

KC7F2 Chemical Structure

CAS No. : 927822-86-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $63 In-stock
5 mg $50 In-stock
10 mg $70 In-stock
50 mg $250 In-stock
100 mg $420 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

KC7F2 is a potent HIF-1 pathway inhibitor and that its potential as a cancer therapy agent warrants further study. Target:HIF in vitro: KC7F2 is the second HIF-1α inhibitor. KC7F2 is shown to inhibit the proliferation of cancer cells, an effect that is increased in hypoxia, while non-tumor cells are less sensitive. KC7F2 decreases HIF-1α levels by downregulating HIF-1α protein synthesis. [2] KC7F2 markedly inhibits HIF-mediated transcription in cells derived from different tumor types, including glioma, breast and prostate cancers and exhibited enhanced cytotoxicity under hypoxia. KC7F2 prevents the activation of HIF-target genes such as Carbonic Anhydrase IX, Matrix Metalloproteinase 2 (MMP2), Endothelin 1 and Enolase 1. KC7F2 works through the down-regulation of HIF-1α protein synthesis, an effect accompanied by the suppression of the phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase (S6K), key regulators of HIF-1α protein synthesis.[1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.7532 mL 8.7661 mL 17.5322 mL
5 mM 0.3506 mL 1.7532 mL 3.5064 mL
10 mM 0.1753 mL 0.8766 mL 1.7532 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

570.38

Formula

C₁₆H₁₆Cl₄N₂O₄S₄

CAS No.

927822-86-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 32 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
KC7F2
Cat. No.:
HY-18777
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