Oroxylin A (Synonyms: Baicalein 6-methyl ether; 6-Methoxybaicalein)

Name: Oroxylin A
Brand: MedChemExpress
SKU: HY-N0560
Rating: 5.0 (18 reviews)

Cat. No.: HY-N0560 Purity: 99.40%: Data Sheet
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Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis.

For research use only. We do not sell to patients.

CAS No. : 480-11-5

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 18 publication(s) in Google Scholar

Other Forms of Oroxylin A:

Oroxylin A (Standard) Get quote

18 Publications Citing Use of MCE Oroxylin A

In Vivo Imaging

RT-PCR

In Vivo Efficacy Study

: Oroxylin A purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 May:276:116327. [Abstract]; Oroxylin A (OA, 1 μg/mL; 46 h) an ngn1 agonist, was used to verify the role of ngn1 in this process to determine whether ROX mediates motor nerve development by inhibiting ngn1. In the presence of OA, ROX-induced motor nerve damage was rescued in transgenic zebrafish Tg(hb9:eGFP).

: Oroxylin A purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 May:276:116327. [Abstract]; Oroxylin A (OA, 1 μg/mL; 46 h) treatment restored the downregulated expression of the ngn1 gene caused by ROX exposure in Tg(hb9:eGFP) zebrafish by activating ngn1.

: Oroxylin A purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 May:276:116327. [Abstract]; Oroxylin A (OA, 1 μg/mL; 46 h) partially rescued the locomotor behavioral deficits associated with ROX exposure in Tg(hb9:eGFP) zebrafish by activating ngn1.

: Oroxylin A purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Jan:55:45-60. [Abstract]; Oroxylin A (OA, 150 μM; 48 h) inhibited mitophagy in CCl₄-treated E47 cells with FUNDC1-OE, as evidenced by downregulation of Parkin and BNIP3 as well as upregulation of TIM23, with subtle changes in FUNDC1.

: Oroxylin A purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Jan:55:45-60. [Abstract]; Effect of Oroxylin A (OA) on cell mitophagy and ferroptosis in CCl₄-treated E47 cells with FUNDC1 overexpression. E47 cells were transfected with scrambled or FUNDC1 plasmid for 48 hrs and were then treated DMSO or OA (150 μM; 48 h) prior to exposure to CCl₄ for 12 hrs. Representative images of C11-BODIPY staining.

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Biological Activity
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References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	33.9 μM Compound: 1, Oroxylin A	Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay	[PMID: 22196122]
HUVEC	IC₅₀	61 μM Compound: 5	Inhibition of trypsin-induced elevation in PAI1 production in HUVEC by ELISA Inhibition of trypsin-induced elevation in PAI1 production in HUVEC by ELISA	[PMID: 9214730]
HepG2	IC₅₀	22.7 μM Compound: 1, Oroxylin A	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 22196122]
KB	IC₅₀	16.1 μM Compound: O, oroxylin-A	Cytotoxicity against multi-drug resistant human KB cells overexpressing mdr1 after 3 days Cytotoxicity against multi-drug resistant human KB cells overexpressing mdr1 after 3 days	[PMID: 18722769]
KB	IC₅₀	31.1 μM Compound: O, oroxylin-A	Cytotoxicity against human KB cells after 3 days Cytotoxicity against human KB cells after 3 days	[PMID: 18722769]
MV4-11	GI₅₀	5.59 μM Compound: 14, Oroxylin	Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay	[PMID: 23411073]
RAW264.7	IC₅₀	16.73 μM Compound: 1, oroxylin A	Cytotoxicity against mouse RAW264.7 cells Cytotoxicity against mouse RAW264.7 cells	[PMID: 22101131]
RAW264.7	IC₅₀	48.9 μM Compound: 6	Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in NO production Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in NO production	[PMID: 37778427]
RS4-11	GI₅₀	40 μM Compound: 14, Oroxylin	Cytotoxicity against human RS4:11 cells harboring wild type FLT3 after 72 hrs by tetrazolium based Ez CyTox cell viability assay Cytotoxicity against human RS4:11 cells harboring wild type FLT3 after 72 hrs by tetrazolium based Ez CyTox cell viability assay	[PMID: 23411073]
SW1353	IC₅₀	> 50 μM Compound: 5	Antiinflammatory activity in PMA-stimulated human SW1353 cells assessed as inhibition of NF-kappaB activation Antiinflammatory activity in PMA-stimulated human SW1353 cells assessed as inhibition of NF-kappaB activation	[PMID: 19555121]

In Vitro

Oroxylin A (20 μM; 24 h) inhibits the growth, proliferation, and migration of MDA-MB-231 cells. Oroxylin A also inhibits the invasion of MDA-MB-231 and inhibits its epithelial-to-mesenchymal transition (EMT) process^[4].
Oroxylin A (20 μM; 24 h) also inhibits the expression of pro-inflammatory cytokines and inhibits the NF-κB signaling pathway^[4].
The anti-inflammatory effect of Oroxylin A is abolished by TNF-α^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

284.26

Formula

C₁₆H₁₂O₅

CAS No.

480-11-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C=C(C2=CC=CC=C2)OC3=CC(O)=C(OC)C(O)=C13

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 62.5 mg/mL (219.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5179 mL	17.5895 mL	35.1791 mL
5 mM	0.7036 mL	3.5179 mL	7.0358 mL
10 mM	0.3518 mL	1.7590 mL	3.5179 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.87%

Select Batch:

Data Sheet (276 KB) SDS (396 KB)

COA (250 KB) LCMS (265 KB)

Handling Instructions (2659 KB)

References

[1]. Zhao K, et al. Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. J Hematol Oncol. 2015 Apr 23;8:41. http://www.ncbi.nlm.nih.gov/pubmed/25902914 [Content Brief]

[2]. Dai Q, et al. Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 in human hepatoma HepG2 cells. Mol Carcinog. 2015 Aug 10. [Content Brief]

[3]. Wei L, et al. Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. Cell Death Dis. 2015 Apr 9 [Content Brief]

[4]. Sun X, et al. Oroxylin A Suppresses the Cell Proliferation, Migration, and EMT via NF-κB Signaling Pathway in Human Breast Cancer Cells. Biomed Res Int. 2019 Jun 23;2019:9241769. [Content Brief]

[5]. Yang X, et al. Oroxylin A inhibits colitis-associated carcinogenesis through modulating the IL-6/STAT3 signaling pathway. Inflamm Bowel Dis. 2013 Aug;19(9):1990-2000. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5179 mL	17.5895 mL	35.1791 mL	87.9477 mL
	5 mM	0.7036 mL	3.5179 mL	7.0358 mL	17.5895 mL
	10 mM	0.3518 mL	1.7590 mL	3.5179 mL	8.7948 mL
	15 mM	0.2345 mL	1.1726 mL	2.3453 mL	5.8632 mL
	20 mM	0.1759 mL	0.8795 mL	1.7590 mL	4.3974 mL
	25 mM	0.1407 mL	0.7036 mL	1.4072 mL	3.5179 mL
	30 mM	0.1173 mL	0.5863 mL	1.1726 mL	2.9316 mL
	40 mM	0.0879 mL	0.4397 mL	0.8795 mL	2.1987 mL
	50 mM	0.0704 mL	0.3518 mL	0.7036 mL	1.7590 mL
	60 mM	0.0586 mL	0.2932 mL	0.5863 mL	1.4658 mL
	80 mM	0.0440 mL	0.2199 mL	0.4397 mL	1.0993 mL
	100 mM	0.0352 mL	0.1759 mL	0.3518 mL	0.8795 mL

Oroxylin A Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oroxylin A480-11-5Baicalein 6-methyl ether 6-MethoxybaicaleinHIF/HIF Prolyl-HydroxylaseAutophagyVirus ProteaseHypoxia-inducible factorsHIFsHIF-PHcolitis-associated cancerchemopreventioninflammationIL-6/STAT3 pathwayInhibitorinhibitorinhibit

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Oroxylin A (Synonyms: Baicalein 6-methyl ether; 6-Methoxybaicalein)

Customer Review

Other Forms of Oroxylin A:

Oroxylin A Related Antibodies

18 Publications Citing Use of MCE Oroxylin A

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All HIF/HIF Prolyl-Hydroxylase Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Oroxylin A Related Antibodies

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Complete Stock Solution Preparation Table

Oroxylin A Related Classifications

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