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Oroxylin A

(Synonyms: Baicalein 6-methyl ether; 6-Methoxybaicalein)
18 Cited Publications
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Based on 18 publication(s) in Google Scholar

Oroxylin A is an active flavonoid compound with strong anti-cancer effects. Oroxylin A inhibits the IL-6/STAT3 pathway and NF-κB signaling, inhibits cell proliferation and induces apoptosis. Oroxylin A inhibits colitis-related carcinogenesis.

For research use only. We do not sell to patients.

  • Purity: 99.40%
  • CAS No.: 480-11-5
  • Formula: C16H12O5
  • Molecular Weight:284.26
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Oroxylin A Chemical Structure
    Oroxylin A Chemical Structure
  • Experimental Validation Results for Oroxylin A
  • Experimental Validation Results for Oroxylin A
  • Experimental Validation Results for Oroxylin A
  • Experimental Validation Results for Oroxylin A
  • Experimental Validation Results for Oroxylin A
CAS No.: 480-11-5
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  • Oroxylin A Chemical Structure
    Oroxylin A Chemical Structure
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    Oroxylin A purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 May:276:116327. [Abstract]

    Customer Validation
     Oroxylin A (OA, 1 μg/mL; 46 h) an ngn1 agonist, was used to verify the role of ngn1 in this process to determine whether ROX mediates motor nerve development by inhibiting ngn1. In the presence of OA, ROX-induced motor nerve damage was rescued in transgenic zebrafish Tg(hb9:eGFP).

  • 1/16

    Oroxylin A purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 May:276:116327. [Abstract]

    Customer Validation
     Oroxylin A (OA, 1 μg/mL; 46 h) treatment restored the downregulated expression of the ngn1 gene caused by ROX exposure in Tg(hb9:eGFP) zebrafish by activating ngn1.

  • 1/16

    Oroxylin A purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 May:276:116327. [Abstract]

    Customer Validation
     Oroxylin A (OA, 1 μg/mL; 46 h) partially rescued the locomotor behavioral deficits associated with ROX exposure in Tg(hb9:eGFP) zebrafish by activating ngn1.

  • 1/16

    Oroxylin A purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Jan:55:45-60. [Abstract]

    Customer Validation
     Oroxylin A (OA, 150 μM; 48 h) inhibited mitophagy in CCl₄-treated E47 cells with FUNDC1-OE, as evidenced by downregulation of Parkin and BNIP3 as well as upregulation of TIM23, with subtle changes in FUNDC1.

  • 1/16

    Oroxylin A purchased from MedChemExpress. Usage Cited in: J Adv Res. 2024 Jan:55:45-60. [Abstract]

    Customer Validation
     Effect of Oroxylin A (OA) on cell mitophagy and ferroptosis in CCl4-treated E47 cells with FUNDC1 overexpression. E47 cells were transfected with scrambled or FUNDC1 plasmid for 48 hrs and were then treated DMSO or OA (150 μM; 48 h) prior to exposure to CCl4 for 12 hrs. Representative images of C11-BODIPY staining.

  • Oroxylin A