1. Metabolic Enzyme/Protease
    Autophagy
  2. HIF/HIF Prolyl-Hydroxylase
    Autophagy

Oroxylin A (Synonyms: Baicalein 6-methyl ether; 6-Methoxybaicalein)

Cat. No.: HY-N0560 Purity: 99.97%
Handling Instructions

Oroxylin A is a natural active flavonoid with strong anticancer effects.

For research use only. We do not sell to patients.

Oroxylin A Chemical Structure

Oroxylin A Chemical Structure

CAS No. : 480-11-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 198 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 264 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Oroxylin A is a natural active flavonoid with strong anticancer effects. IC50 value: Target: In vitro: Oroxylin A suppressed the MDM2-mediated degradation of p53 via downregulating MDM2 transcription in wt-p53 cancer cells [1]. Oroxylin A remarkably reduced the generation of lactate and glucose uptake under hypoxia in HepG2 cells, inhibited HIF-1α expression and its stability [2]. Oroxylin A promotes superoxide dismutase (SOD2) gene expression through SIRT3-regulated DNA-binding activity of FOXO3a and increases the activity of SOD2 by promoting SIRT3-mediated deacetylation [3]. In vivo: Oroxylin A inhibited the tumor growth of nude mice-inoculated MCF-7 or HCT116 cells. The expression of MDM2 protein in tumor tissue was downregulated by oroxylin A as well [1].

References
Molecular Weight

284.26

Formula

C₁₆H₁₂O₅

CAS No.

480-11-5

SMILES

O=C1C=C(C2=CC=CC=C2)OC3=CC(O)=C(OC)C(O)=C13

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 32 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Oroxylin A
Cat. No.:
HY-N0560
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