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Nobiletin 

Cat. No.: HY-N0155 Purity: 99.96%
Data Sheet SDS Handling Instructions

Nobiletin, a natural polymethoxylated flavone, is identified as a clock amplitude-enhancing small molecule.

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Nobiletin Chemical Structure

Nobiletin Chemical Structure

CAS No. : 478-01-3

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
5 mg $50 In-stock
10 mg $80 In-stock
50 mg $160 In-stock
100 mg $260 In-stock
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500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

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  • References

Description

Nobiletin, a natural polymethoxylated flavone, is identified as a clock amplitude-enhancing small molecule. IC50 value: Target: In vitro: Although NGF alone had little effect on the CRE-dependent transcription, NGF markedly enhanced the CRE-dependent transcription induced by nobiletin[1]. Nobiletin, up to 100 μM without cytotoxicity, significantly decreased motility, migration and invasion as well as enzymatic activities, protein levels and mRNA expressions of matrix metalloproteinase (MMP)-2 and MMP-9 in U2OS and HOS cells[3]. In vivo: When administered to diet-induced obese (DIO) mice, NOB strongly counteracted metabolic syndrome and augmented energy expenditure and locomotor activity in a Clock gene-dependent manner. In db/db mutant mice, the clock is also required for the mitigating effects of NOB on metabolic disorders[2].

References
Molecular Weight

402.39

Formula

C₂₁H₂₂O₈

CAS No.

478-01-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 31 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Nobiletin
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