1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Acacetin

Acacetin (Synonyms: 5,7-Dihydroxy-4'-methoxyflavone)

Cat. No.: HY-N0451 Purity: 99.84%
Handling Instructions

Acacetin (5,7-Dihydroxy-4'-methoxyflavone) was a 4.0-fold and 5.5-fold more potent inhibitor of BACE-1 than oleanolic acid and maslinic acid, respectively.

For research use only. We do not sell to patients.

Acacetin Chemical Structure

Acacetin Chemical Structure

CAS No. : 480-44-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 84 In-stock
Estimated Time of Arrival: December 31
25 mg USD 132 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Acacetin (5,7-Dihydroxy-4'-methoxyflavone) was a 4.0-fold and 5.5-fold more potent inhibitor of BACE-1 than oleanolic acid and maslinic acid, respectively. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) significantly suppressed the photoreceptor collapse. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) significantly reduces the Aβ levels by interfering with human APP proteolytic processing and BACE-1 expression. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) inhibited the generation of the APP-CTF by affecting APP cleavage. Acacetin (5,7-Dihydroxy-4'-methoxyflavone) prolongs lifespan of significantly in the dose dependent manner[1].

Molecular Weight

284.26

Formula

C₁₆H₁₂O₅

CAS No.

480-44-4

SMILES

O=C1C=C(C2=CC=C(OC)C=C2)OC3=CC(O)=CC(O)=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 37 mg/mL (130.16 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5179 mL 17.5895 mL 35.1791 mL
5 mM 0.7036 mL 3.5179 mL 7.0358 mL
10 mM 0.3518 mL 1.7590 mL 3.5179 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.32 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.84%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Acacetin5,7-Dihydroxy-4'-methoxyflavonePotassium ChannelKcsAInhibitorinhibitorinhibit

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Acacetin
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HY-N0451
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