Art. -Nr.: HY-N0752

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Scutellarein

(Synonyms: 6-Hydroxyapigenin; 4',5,6,7-Tetrahydroxyflavone)

14 Cited Publications

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Based on 14 publication(s) in Google Scholar

Scutellarein is a natural flavonoid compound with anti-inflammatory effects.

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Reinheit: 99.39%
CAS. Nr.: 529-53-3
Formel: C₁₅H₁₀O₆
Molecular Weight:286.24

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Scutellarein Chemical Structure

CAS. Nr.: 529-53-3

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (14)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Scutellarein is a natural flavonoid compound with anti-inflammatory effects.

Alle Src Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	16.4 μM Compound: 11	Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assay Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assay	[PMID: 24955889]
MV4-11	IC₅₀	27.07 μM Compound: 23	Antiproliferation activity against human MV4-11 cells assessed as reduction in cell viability measured by Cell-titer-Glo assay Antiproliferation activity against human MV4-11 cells assessed as reduction in cell viability measured by Cell-titer-Glo assay	[PMID: 32088124]
RBL-2H3	IC₅₀	67.2 μM Compound: 3	Antihistaminic activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta-hexosaminidase release preincubated for 10 mins before DNP-BSA challenge Antihistaminic activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta-hexosaminidase release preincubated for 10 mins before DNP-BSA challenge	[PMID: 14510616]

In Vitro

Scutellarein (0-200 μM, 24 h) inhibits NO production, reduces the mRNA expression levels of iNOS and TNF-α in LPS-activated RAW264.7 cells^[1].
Scutellarein (0-50 μM, 24 h) inhibits proliferation, migration, colony formation and induces the apoptosis of HT1080 cells^[3].
Scutellarein (0-50 μM, 24 h) inhibits MMP-2, -9 and -14 expression and NF-κB activation in HT1080 cells^[3].
Scutellarein shows DPPH, ABTS+·, ·OH radical-scavenging activity (IC₅₀: 16.84 μM, 3.00 μM, 0.31 mM respectively)^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Scutellarein (50 mg/kg, in diet, 16 weeks) shows anti-obesity effects, and shows lipid lowering and liver protective effects in HFD mice^[2].
Scutellarein (50 and 500 mg/kg) inhibits tumor growth in a mouse HT108 xenograft model^[3].
Scutellarein (0-1.40 mmol/kg, p.o.) improves neuronal injury, and protects rats from cerebral ischemia^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

HFD mice^[2]
Dosage:

50 mg/kg
Administration:

in diet, 16 weeks
Result:

Reduced lipid accumulation and levels of inflammatory factors in the liver.
Reduced the Body Weight.

Chemical Information

CAS. Nr. 529-53-3
Appearance Solid
Molecular Weight 286.24
Formel C₁₅H₁₀O₆
Color Light yellow to yellow
SMILES

O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=C(O)C(O)=C13
Synonyms

6-Hydroxyapigenin; 4',5,6,7-Tetrahydroxyflavone
Structure Classification
- Flavonoids
- Flavones
- Phenols
- Polyphenols
Initial Source
- Plants
- Labiatae
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (14)

All In Vivo Efficacy StudyCell Proliferation/Viability AssayHistological Imaging/StainingWBOthers

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Journal Impact Factor

Nucleic Acids Res

COVID19 Drug Repository: text-mining the literature in search of putative COVID19 therapeutics. [Abstract]

2021 Jan 8;49(D1):D1113-D1121. PMID: 33166390
Acta Pharm Sin B

Chrysin serves as a novel inhibitor of DGK α/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC). [Abstract]

2021 Jan;11(1):143-155. PMID: 33532186
Cell Chem Biol

Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses. [Abstract]

2022 Jul 21;29(7):1113-1125.e6. PMID: 35728599
Int J Mol Med

Scutellarein regulates the PTEN/AKT/NFκB signaling pathway to reduce pirarubicin related liver inflammation. [Abstract]

2023 Jul;52(1):55. PMID: 37232353

Scutellarein purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2023 Jul;52(1):55. [Abstract]

Effects of THP and Sc (Scutellarein: 100 mg/kg) on body weight in rats over 6 weeks.

Scutellarein purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2023 Jul;52(1):55. [Abstract]

Effects of THP and Sc (Scutellarein: 100 mg/kg) on the morphology of rat liver tissue.

Scutellarein purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2023 Jul;52(1):55. [Abstract]

Effects of THP and Sc (Scutellarein: 100 mg/kg) on the expression of p65, AKT, PTEN and IκBα proteins in rat liver.

Scutellarein purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2023 Jul;52(1):55. [Abstract]

The optimal concentration of Sc (Scutellarein) for treating hepatocytes was screened under a treatment condition of 5 µmol/L THP.
Phytother Res

Scutellarein Attenuates Intervertebral Disc Degeneration by Promoting PINK1/Parkin-Mediated Mitophagy to Alleviate Inflammation, Ferroptosis, and Mitochondrial Dysfunction in Nucleus Pulposus Cells. [Abstract]

2026 May;40(5):2986-3008. PMID: 41815012
Biochem Pharmacol

Scutellarein ameliorates pulmonary arterial hypertension via sirtuin 1 mediated deacetylation of nicotinamide nucleotide transhydrogenase. [Abstract]

2025 Apr 4:116932. PMID: 40189160
Food Front

2026 May 28;7(4):e70301.
Pharmaceuticals (Basel)

Discovery of Plant-Derived Natural Compounds as Novel GABA Aminotransferase Inhibitors: Structure-Based Discovery, Experimental Validation, and Molecular Dynamics Analysis. [Abstract]

2026 Feb 12;19(2):307. PMID: 41754847

Scutellarein purchased from MedChemExpress. Usage Cited in: Pharmaceuticals (Basel). 2026 Feb 12;19(2):307. [Abstract]

ell-based inhibitory effects of plant-derived aglycones on GABA-AT activity in HepG2 cells. Cells were treated with quercetin, salvianolic acid A, scutellarein, or vigabatrin at the indicated concentration (1, 10, 100 μM) for 2 days, followed by cell lysis. Intracellular GABA-AT activity was quantified using a resazurin-based coupled assay.
Pharmaceuticals (Basel)

Bruceine D Identified as a Drug Candidate against Breast Cancer by a Novel Drug Selection Pipeline and Cell Viability Assay. [Abstract]

2022 Jan 31;15(2):179. PMID: 35215292
Mol Med Rep

Food therapy of scutellarein ameliorates pirarubicin‑induced cardiotoxicity in rats by inhibiting apoptosis and ferroptosis through regulation of NOX2‑induced oxidative stress. [Abstract]

2024 May;29(5):84. PMID: 38516760
J Immunol

SARS-CoV-2 NSP13 Inhibits Type I IFN Production by Degradation of TBK1 via p62-Dependent Selective Autophagy. [Abstract]

2022 Feb 1;208(3):753-761. PMID: 34996837
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
Medicine (Baltimore)

Scutellarein attenuates alcohol-induced hepatocyte injury by modulating NF-κB and NRF2 signaling pathways. [Abstract]

2025 Sep 26;104(39):e44506. PMID: 41029150
Andrologia

Scutellarein stimulates human sperm function by increasing the levels of intracellular calcium and tyrosine phosphorylation. [Abstract]

2022 Dec;54(11):e14625. PMID: 36257765

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 30 mg/mL (104.81 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4936 mL

17.4679 mL

34.9357 mL

5 mM

0.6987 mL

3.4936 mL

6.9871 mL

10 mM

0.3494 mL

1.7468 mL

3.4936 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (7.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (7.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sung NY, et al. Scutellarein Reduces Inflammatory Responses by Inhibiting Src Kinase Activity. Korean J Physiol Pharmacol. 2015 Sep;19(5):441-9.

[2]. Lin Y, et al. Novel anti-obesity effect of scutellarein and potential underlying mechanism of actions. Biomed Pharmacother. 2019 Sep;117:109042. [Content Brief]

[3]. Shi X, et al. Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo. Int J Mol Med. 2015 Jan;35(1):31-8. [Content Brief]

[4]. Qian LH, et al. Synthesis and bio-activity evaluation of scutellarein as a potent agent for the therapy of ischemic cerebrovascular disease. Int J Mol Sci. 2011;12(11):8208-16. [Content Brief]

[5]. Tang H, et al. Neuroprotective effects of scutellarin and scutellarein on repeatedly cerebral ischemia-reperfusion in rats. Pharmacol Biochem Behav. 2014 Mar;118:51-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.4936 mL	17.4679 mL	34.9357 mL	87.3393 mL
	5 mM	0.6987 mL	3.4936 mL	6.9871 mL	17.4679 mL
	10 mM	0.3494 mL	1.7468 mL	3.4936 mL	8.7339 mL
	15 mM	0.2329 mL	1.1645 mL	2.3290 mL	5.8226 mL
	20 mM	0.1747 mL	0.8734 mL	1.7468 mL	4.3670 mL
	25 mM	0.1397 mL	0.6987 mL	1.3974 mL	3.4936 mL
	30 mM	0.1165 mL	0.5823 mL	1.1645 mL	2.9113 mL
	40 mM	0.0873 mL	0.4367 mL	0.8734 mL	2.1835 mL
	50 mM	0.0699 mL	0.3494 mL	0.6987 mL	1.7468 mL
	60 mM	0.0582 mL	0.2911 mL	0.5823 mL	1.4557 mL
	80 mM	0.0437 mL	0.2183 mL	0.4367 mL	1.0917 mL
	100 mM	0.0349 mL	0.1747 mL	0.3494 mL	0.8734 mL

Keywords

Scutellarein

14 Cited Publications

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Publications Citing Use of MedChemExpress (MCE) Scutellarein

Alle Src Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (14)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Scutellarein Related Classifications

HY-N0752 Related Classifications