2. Protein Tyrosine Kinase/RTK Autophagy Anti-infection
  3. Src Autophagy SARS-CoV
  4. Scutellarein

Scutellarein  (Synonyms: 6-Hydroxyapigenin; 4',5,6,7-Tetrahydroxyflavone)

Cat. No.: HY-N0752 Purity: 99.39%
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Scutellarein is a natural flavonoid compound with anti-inflammatory effects.

For research use only. We do not sell to patients.

CAS No. : 529-53-3

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10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 13 publication(s) in Google Scholar

Other Forms of Scutellarein:

Scutellarein Related Antibodies

Top Publications Citing Use of Products

    Scutellarein purchased from MedChemExpress. Usage Cited in: Pharmaceuticals (Basel). 2026 Feb 12;19(2):307.

    ell-based inhibitory effects of plant-derived aglycones on GABA-AT activity in HepG2 cells. Cells were treated with quercetin, salvianolic acid A, scutellarein, or vigabatrin at the indicated concentration (1, 10, 100 μM) for 2 days, followed by cell lysis. Intracellular GABA-AT activity was quantified using a resazurin-based coupled assay.

    Scutellarein purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2023 Jul;52(1):55.  [Abstract]

    Effects of THP and Sc (Scutellarein: 100 mg/kg) on ​​body weight in rats over 6 weeks.

    Scutellarein purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2023 Jul;52(1):55.  [Abstract]

    Effects of THP and Sc (Scutellarein: 100 mg/kg) on ​​the morphology of rat liver tissue.

    Scutellarein purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2023 Jul;52(1):55.  [Abstract]

    Effects of THP and Sc (Scutellarein: 100 mg/kg) on ​​the expression of p65, AKT, PTEN and IκBα proteins in rat liver.

    Scutellarein purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2023 Jul;52(1):55.  [Abstract]

    The optimal concentration of Sc (Scutellarein) for treating hepatocytes was screened under a treatment condition of 5 µmol/L THP.

    View All Src Isoform Specific Products:

    View All Isoforms
    Lck Fyn Blk Fgr Hck Lyn Yes SRC-3

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Scutellarein is a natural flavonoid compound with anti-inflammatory effects.

    Cellular Effect
    Cell Line Type Value Description References
    HEK293 EC50
    16.4 μM
    Compound: 11
    Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assay
    Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assay
    		[PMID: 24955889]
    MV4-11 IC50
    27.07 μM
    Compound: 23
    Antiproliferation activity against human MV4-11 cells assessed as reduction in cell viability measured by Cell-titer-Glo assay
    Antiproliferation activity against human MV4-11 cells assessed as reduction in cell viability measured by Cell-titer-Glo assay
    		[PMID: 32088124]
    RBL-2H3 IC50
    67.2 μM
    Compound: 3
    Antihistaminic activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta-hexosaminidase release preincubated for 10 mins before DNP-BSA challenge
    Antihistaminic activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced beta-hexosaminidase release preincubated for 10 mins before DNP-BSA challenge
    		[PMID: 14510616]
    In Vitro

    Scutellarein (0-200 μM, 24 h) inhibits NO production, reduces the mRNA expression levels of iNOS and TNF-α in LPS-activated RAW264.7 cells[1].
    Scutellarein (0-50 μM, 24 h) inhibits proliferation, migration, colony formation and induces the apoptosis of HT1080 cells[3].
    Scutellarein (0-50 μM, 24 h) inhibits MMP-2, -9 and -14 expression and NF-κB activation in HT1080 cells[3].
    Scutellarein shows DPPH, ABTS+·, ·OH radical-scavenging activity (IC50: 16.84 μM, 3.00 μM, 0.31 mM respectively)[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Scutellarein Related Antibodies
    In Vivo

    Scutellarein (50 mg/kg, in diet, 16 weeks) shows anti-obesity effects, and shows lipid lowering and liver protective effects in HFD mice[2].
    Scutellarein (50 and 500 mg/kg) inhibits tumor growth in a mouse HT108 xenograft model[3].
    Scutellarein (0-1.40 mmol/kg, p.o.) improves neuronal injury, and protects rats from cerebral ischemia[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: HFD mice[2]
    Dosage: 50 mg/kg
    Administration: in diet, 16 weeks
    Result: Reduced lipid accumulation and levels of inflammatory factors in the liver.
    Reduced the Body Weight.
    Molecular Weight

    286.24

    Formula

    C15H10O6
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O=C1C=C(C2=CC=C(O)C=C2)OC3=CC(O)=C(O)C(O)=C13
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 30 mg/mL (104.81 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.4936 mL 17.4679 mL 34.9357 mL
    5 mM 0.6987 mL 3.4936 mL 6.9871 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (7.27 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (7.27 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.39%

    SDS (393 KB)

    COA (248 KB) HNMR (248 KB) RP-HPLC (260 KB) MS (68 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.4936 mL 17.4679 mL 34.9357 mL 87.3393 mL
    5 mM 0.6987 mL 3.4936 mL 6.9871 mL 17.4679 mL
    10 mM 0.3494 mL 1.7468 mL 3.4936 mL 8.7339 mL
    15 mM 0.2329 mL 1.1645 mL 2.3290 mL 5.8226 mL
    20 mM 0.1747 mL 0.8734 mL 1.7468 mL 4.3670 mL
    25 mM 0.1397 mL 0.6987 mL 1.3974 mL 3.4936 mL
    30 mM 0.1165 mL 0.5823 mL 1.1645 mL 2.9113 mL
    40 mM 0.0873 mL 0.4367 mL 0.8734 mL 2.1835 mL
    50 mM 0.0699 mL 0.3494 mL 0.6987 mL 1.7468 mL
    60 mM 0.0582 mL 0.2911 mL 0.5823 mL 1.4557 mL
    80 mM 0.0437 mL 0.2183 mL 0.4367 mL 1.0917 mL
    100 mM 0.0349 mL 0.1747 mL 0.3494 mL 0.8734 mL
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    Scutellarein Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Scutellarein529-53-36-Hydroxyapigenin 4',5,6,7-TetrahydroxyflavoneSrcAutophagySARS-CoVSARS coronavirusInhibitorinhibitorinhibit

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