1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase

Vadadustat (Synonyms: PG-1016548; AKB-6548)

Cat. No.: HY-101277 Purity: 98.02%
Handling Instructions

Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.

For research use only. We do not sell to patients.

Vadadustat Chemical Structure

Vadadustat Chemical Structure

CAS No. : 1000025-07-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 118 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
2 mg USD 70 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 190 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 490 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 690 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.

In Vitro

Vadadustat induces endogenous erythropoietin synthesis and enhances iron mobilization. Vadadustat is well-tolerated in healthy volunteers and patients with chronic kidney disease, where it increases reticulocytes, plasma EPO, and Hb levels in a dose-dependent manner. The increase in plasma EPO levels seen with vadadustat is comparable in magnitude to that occurring physiologically at moderate altitude and shows a normal diurnal pattern with a return to baseline levels prior to the next dose. Vadadustat improves iron homeostasis by decreasing hepcidin and increasing transferrin levels. once-daily oral administration of vadadustat, titrated to increase and maintain Hb in the target range, may provide multiple advantages over conventional ESAs[1]. Vadadustat is observed to have a half-life of approximately 4.5 hours. Overall, patients demonstrate an increase in Hb levels, from 9.91 g/dL at baseline to 10.54 g/dL by day 29. Ferritin levels decrease from 334.1 ng/mL at baseline to 271.7 ng/mL by day 29[2].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (326.05 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2605 mL 16.3026 mL 32.6051 mL
5 mM 0.6521 mL 3.2605 mL 6.5210 mL
10 mM 0.3261 mL 1.6303 mL 3.2605 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

306.7

Formula

C₁₄H₁₁ClN₂O₄

CAS No.

1000025-07-9

SMILES

O=C(O)CNC(C1=NC=C(C2=CC=CC(Cl)=C2)C=C1O)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Vadadustat
Cat. No.:
HY-101277
Quantity:

Vadadustat

Cat. No.: HY-101277