1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase

Daprodustat (Synonyms: GSK1278863)

Cat. No.: HY-17608 Purity: 99.95%
Handling Instructions

Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for the treatment of anemia associated with chronic kidney disease.

For research use only. We do not sell to patients.

Daprodustat Chemical Structure

Daprodustat Chemical Structure

CAS No. : 960539-70-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Estimated Time of Arrival: December 31
100 mg USD 900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for the treatment of anemia associated with chronic kidney disease.

In Vitro

GSK1278863 is an orally administered small-molecule PHI, and stimulates endogenous EPO synthesis and induce effective erythropoiesis[1]. GSK1278863 has been shown to increase erythropoietin levels, leading to increases in hemoglobin, hematocrit and red blood cell numbers[2].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : 19.5 mg/mL (49.56 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5417 mL 12.7087 mL 25.4175 mL
5 mM 0.5083 mL 2.5417 mL 5.0835 mL
10 mM 0.2542 mL 1.2709 mL 2.5417 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

393.43

Formula

C₁₉H₂₇N₃O₆

CAS No.

960539-70-2

SMILES

O=C(O)CNC(C(C(N1C2CCCCC2)=O)C(N(C3CCCCC3)C1=O)=O)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.95%

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Daprodustat
Cat. No.:
HY-17608
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Daprodustat

Cat. No.: HY-17608