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Daprodustat

(Synonyms: GSK1278863)
20 Cited Publications
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Based on 20 publication(s) in Google Scholar

Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor being developed for the treatment of anemia associated with chronic kidney disease.

For research use only. We do not sell to patients.

  • Purity: 99.91%
  • CAS No.: 960539-70-2
  • Formula: C19H27N3O6
  • Molecular Weight:393.43
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Daprodustat Chemical Structure
    Daprodustat Chemical Structure
  • Experimental Validation Results for Daprodustat
  • Experimental Validation Results for Daprodustat
  • Experimental Validation Results for Daprodustat
  • Experimental Validation Results for Daprodustat
  • Experimental Validation Results for Daprodustat
  • Experimental Validation Results for Daprodustat
  • Experimental Validation Results for Daprodustat
  • Experimental Validation Results for Daprodustat
CAS No.: 960539-70-2
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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All HIF/HIF Prolyl-Hydroxylase Isoforms

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  • Daprodustat Chemical Structure
    Daprodustat Chemical Structure
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    Daprodustat purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jan 24;16(1):985. [Abstract]

    Customer Validation
     Representative immunoblots and quantitative analysis of pro IL-1β protein levels in BMDMs under control, LPS, LPS + ML-SA5, LPS + ML-SA5 + Roxadustat, LPS + ML-SA5 + Vadadustat, LPS + ML-SA5 + Daprodustat (GSK1278863) (250uM), Roxadustat, Vadadustat, or Daprodustat (GSK1278863) (250uM). All treatments were for 24 h. n = 3–6.

  • 1/16

    Daprodustat purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Mar;15(3):1497-1513. [Abstract]

    Customer Validation
     The measurements of thrombus wet weight indicate that ASP, CK and Daprodustat (Dap), whether administered alone or in combination, exhibited sound antithrombotic effects. Furthermore, the combined use of ASP and CK displayed superior efficacy compared to their individual use, and similar effects were observed with the combination of Dap and ASP. SD rats (200–220 g) were randomly divided into seven groups: control (ctrl), model (mod), ASP (10 mg/kg), CK (20 mg/kg), Dap (10 mg/kg), ASP + CK (5 + 10 mg/kg), and ASP + Dap (5 + 5 mg/kg) groups. Continuous intraperitoneal administration of drugs was performed for 14 days. Anesthesia was induced in rats 1 h after the final administration, and blunt dissection to isolate the carotid artery.

  • 1/16

    Daprodustat purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Mar;15(3):1497-1513. [Abstract]

    Customer Validation
     The measurements of thrombus length indicate that ASP, CK and Daprodustat (Dap), whether administered alone or in combination, exhibited sound antithrombotic effects. Furthermore, the combined use of ASP and CK displayed superior efficacy compared to their individual use, and similar effects were observed with the combination of Dap and ASP. SD rats (200–220 g) were randomly divided into seven groups: control (ctrl), model (mod), ASP (10 mg/kg), CK (20 mg/kg), Dap (10 mg/kg), ASP + CK (5 + 10 mg/kg), and ASP + Dap (5 + 5 mg/kg) groups. Continuous intraperitoneal administration of drugs was performed for 14 days. Anesthesia was induced in rats 1 h after the final administration, and blunt dissection to isolate the carotid artery.

  • 1/16

    Daprodustat purchased from MedChemExpress. Usage Cited in: Cell Rep. 2021 Apr 20;35(3):109020. [Abstract]

    Customer Validation
     Calu-3 cells were treated with increasing concentrations of Daprodustat (GSK: 1278863, 0-50 μM), Molidustat (Bay 85-3934), and Roxadustat (FG-4592) and were infected with SARS-CoV-2, and viral replication was assessed 24 h later. Data are expressed relative to UT cells.

  • 1/16

    Daprodustat purchased from MedChemExpress. Usage Cited in: iScience. 2023 Nov 9;26(12):108424. [Abstract]

    Customer Validation
     Immunofluorescence images depicting increased EPAS1 expression (red) in undifferentiated spermatogonia from culture following 24 h exposure to 250 μM Daprodustat, as compared to a vehicle (DMSO) control.

  • 1/16

    Daprodustat purchased from MedChemExpress. Usage Cited in: iScience. 2023 Nov 9;26(12):108424. [Abstract]

    Customer Validation
     Quantification of corrected total cell fluorescence (CTCF) of EPAS1 expression comparing undifferentiated spermatogonia from culture following 24 h exposure to 250 μM Daprodustat, as compared to a vehicle (DMSO) control.

  • 1/16

    Daprodustat purchased from MedChemExpress. Usage Cited in: iScience. 2023 Nov 9;26(12):108424. [Abstract]

    Customer Validation
     Cell viability (Live/dead flow cytometry assay) of undifferentiated spermatogonia from culture following 24 h exposure to 250 μM Daprodustat or vehicle (DMSO control).

  • 1/16

    Daprodustat purchased from MedChemExpress. Usage Cited in: iScience. 2023 Nov 9;26(12):108424. [Abstract]

    Customer Validation
     Bulk RNA-seq analysis comparing undifferentiated spermatogonia from culture treated with either DMSO or 250 M Daprodustat. Downregulated genes denoted by purple circles and upregulated genes denoted by yellow circles had a false discovery rate (FDR) of p < 0.05.

  • Daprodustat