1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase

Daprodustat (Synonyms: GSK1278863)

Cat. No.: HY-17608 Purity: 99.95%
Handling Instructions

Daprodustat is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for treatment of anemia associated with chronic kidney disease.

For research use only. We do not sell to patients.

Daprodustat Chemical Structure

Daprodustat Chemical Structure

CAS No. : 960539-70-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 132 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 900 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Daprodustat is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for treatment of anemia associated with chronic kidney disease.

In Vitro

GSK1278863 is an orally administered small-molecule PHI, and stimulates endogenous EPO synthesis and induce effective erythropoiesis[1]. GSK1278863 has been shown to increase erythropoietin levels, leading to increases in hemoglobin, hematocrit and red blood cell numbers[2].

Clinical Trial
References
Molecular Weight

393.43

Formula

C₁₉H₂₇N₃O₆

CAS No.

960539-70-2

SMILES

O=C(O)CNC(C(C(N1C2CCCCC2)=O)C(N(C3CCCCC3)C1=O)=O)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 19.5 mg/mL (Need ultrasonic and warming)

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.95%

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Daprodustat
Cat. No.:
HY-17608
Quantity: