1. Metabolic Enzyme/Protease
  2. HIF/HIF Prolyl-Hydroxylase

Daprodustat (Synonyms: GSK1278863)

Cat. No.: HY-17608 Purity: 99.95%
Data Sheet SDS Handling Instructions

Daprodustat is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for treatment of anemia associated with chronic kidney disease.

For research use only. We do not sell to patients.
Daprodustat Chemical Structure

Daprodustat Chemical Structure

CAS No. : 960539-70-2

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  • Biological Activity

  • Protocol

  • Technical Information

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  • References

Description

Daprodustat is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for treatment of anemia associated with chronic kidney disease.

In Vitro

GSK1278863 is an orally administered small-molecule PHI, and stimulates endogenous EPO synthesis and induce effective erythropoiesis[1]. GSK1278863 has been shown to increase erythropoietin levels, leading to increases in hemoglobin, hematocrit and red blood cell numbers[2].

References
Molecular Weight

393.43

Formula

C₁₉H₂₇N₃O₆

CAS No.

960539-70-2

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: < 6.8 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.95%

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Product Name:
Daprodustat
Cat. No.:
HY-17608
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