1. PROTAC
  2. Ligand for E3 Ligase
  3. (S,R,S)-AHPC-propargyl

(S,R,S)-AHPC-propargyl (Synonyms: VH032-propargyl; VHL ligand 7)

Cat. No.: HY-126456 Purity: 98.12%
Handling Instructions

(S,R,S)-AHPC-propargyl (VH032-propargyl) is a VHL ligand which is used in “click reaction” for PROTACs.

For research use only. We do not sell to patients.

(S,R,S)-AHPC-propargyl Chemical Structure

(S,R,S)-AHPC-propargyl Chemical Structure

CAS No. : 2098799-78-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 143 In-stock
Estimated Time of Arrival: December 31
10 mg USD 130 In-stock
Estimated Time of Arrival: December 31
25 mg USD 260 In-stock
Estimated Time of Arrival: December 31
50 mg USD 445 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

(S,R,S)-AHPC-propargyl (VH032-propargyl) is a VHL ligand which is used in “click reaction” for PROTACs[1].

Molecular Weight

526.65

Formula

C₂₇H₃₄N₄O₅S

CAS No.

2098799-78-9

SMILES

CC(N=CS1)=C1C2=CC=C(CNC([[email protected]@H]3C[[email protected]@H](O)CN3C([[email protected]@H](NC(COCC#C)=O)C(C)(C)C)=O)=O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (189.88 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8988 mL 9.4940 mL 18.9879 mL
5 mM 0.3798 mL 1.8988 mL 3.7976 mL
10 mM 0.1899 mL 0.9494 mL 1.8988 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.75 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.75 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.75 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

(S,R,S)-AHPC-propargylVH032-propargylVHL ligand 7VHL ligand7VHL ligand-7Ligand for E3 LigaseE3 ligase-recruiting MoietyVHLligandPROTACInhibitorinhibitorinhibit

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Product name:
(S,R,S)-AHPC-propargyl
Cat. No.:
HY-126456
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