1. PROTAC
  2. Ligand for E3 Ligase
  3. Thalidomide-propargyl

Thalidomide-propargyl 

Cat. No.: HY-126457 Purity: 99.97%
Handling Instructions

Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs.

For research use only. We do not sell to patients.

Thalidomide-propargyl Chemical Structure

Thalidomide-propargyl Chemical Structure

CAS No. : 2098487-39-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 86 In-stock
Estimated Time of Arrival: December 31
2 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 135 In-stock
Estimated Time of Arrival: December 31
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Description

Thalidomide-propargyl is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-propargyl can be connected to the ligand for protein by a linker to form the IMiD containing PROTACs[1].

IC50 & Target[1]

Cereblon

 

Molecular Weight

312.28

Formula

C₁₆H₁₂N₂O₅

CAS No.

2098487-39-7

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3OCC#C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

Thalidomide-propargylLigand for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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Thalidomide-propargyl
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