1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugates
  3. (S,R,S)-AHPC-amido-C7-acid

(S,R,S)-AHPC-amido-C7-acid incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design PROTACs.

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(S,R,S)-AHPC-amido-C7-acid Chemical Structure

(S,R,S)-AHPC-amido-C7-acid Chemical Structure

CAS No. : 2172819-76-8

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Based on 1 publication(s) in Google Scholar

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Description

(S,R,S)-AHPC-amido-C7-acid incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker. (S,R,S)-AHPC-amido-C5-acid can be used to design PROTACs[1].

Molecular Weight

600.77

Formula

C31H44N4O6S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(CCCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (166.45 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6645 mL 8.3227 mL 16.6453 mL
5 mM 0.3329 mL 1.6645 mL 3.3291 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6645 mL 8.3227 mL 16.6453 mL 41.6133 mL
5 mM 0.3329 mL 1.6645 mL 3.3291 mL 8.3227 mL
10 mM 0.1665 mL 0.8323 mL 1.6645 mL 4.1613 mL
15 mM 0.1110 mL 0.5548 mL 1.1097 mL 2.7742 mL
20 mM 0.0832 mL 0.4161 mL 0.8323 mL 2.0807 mL
25 mM 0.0666 mL 0.3329 mL 0.6658 mL 1.6645 mL
30 mM 0.0555 mL 0.2774 mL 0.5548 mL 1.3871 mL
40 mM 0.0416 mL 0.2081 mL 0.4161 mL 1.0403 mL
50 mM 0.0333 mL 0.1665 mL 0.3329 mL 0.8323 mL
60 mM 0.0277 mL 0.1387 mL 0.2774 mL 0.6936 mL
80 mM 0.0208 mL 0.1040 mL 0.2081 mL 0.5202 mL
100 mM 0.0166 mL 0.0832 mL 0.1665 mL 0.4161 mL
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(S,R,S)-AHPC-amido-C7-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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(S,R,S)-AHPC-amido-C7-acid
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