1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2

(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 

Cat. No.: HY-131387
Handling Instructions

(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 can be used in PROTAC BRD4 Degrader-5 (HY-133737) and PROTAC BRD4 Degrader-5-CO-PEG3-N3 (HY-133736).

For research use only. We do not sell to patients.

(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 Chemical Structure

(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 Chemical Structure

CAS No. : 2409538-69-6

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Description

(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the a VHL ligand and a linker. (S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2 can be used in PROTAC BRD4 Degrader-5 (HY-133737) and PROTAC BRD4 Degrader-5-CO-PEG3-N3 (HY-133736)[1].

IC50 & Target

VHL

 

In Vitro

PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].
PROTAC BRD4 Degrader-5-CO-PEG3-N3 is a PROTAC-linker Conjugate for PAC, comprises the BRD4 degrader GNE-987 and PEG-based linker[1].

Molecular Weight

633.80

Formula

C₃₁H₄₇N₅O₇S

CAS No.

2409538-69-6

SMILES

NCCOCCOCCOCC(N[[email protected]@H](C(C)(C)C)C(N1[[email protected]@H](C[[email protected]](C1)O)C(N[[email protected]](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2E3 Ligase Ligand-Linker ConjugateInhibitorinhibitorinhibit

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(S,R,S)-AHPC-Me-CO-CH2-PEG3-NH2
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HY-131387
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