1. Antibody-drug Conjugate/ADC Related
    PROTAC
  2. PROTAC-linker Conjugate for PAC
    ADC Cytotoxin
  3. PROTAC BRD4 Degrader-5-CO-PEG3-N3

PROTAC BRD4 Degrader-5-CO-PEG3-N3 

Cat. No.: HY-133736 Purity: 99.54%
Handling Instructions

PROTAC BRD4 Degrader-5-CO-PEG3-N3 (Compound 2) is a PROTAC-linker Conjugate for PAC, comprises the BRD4 degrader GNE-987 and PEG-based linker.

For research use only. We do not sell to patients.

PROTAC BRD4 Degrader-5-CO-PEG3-N3 Chemical Structure

PROTAC BRD4 Degrader-5-CO-PEG3-N3 Chemical Structure

Size Price Stock Quantity
10 mg USD 2500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

PROTAC BRD4 Degrader-5-CO-PEG3-N3 (Compound 2) is a PROTAC-linker Conjugate for PAC, comprises the BRD4 degrader GNE-987 and PEG-based linker[1].

Molecular Weight

1231.87

Formula

C₅₈H₇₅ClN₁₂O₁₂S₂

SMILES

O=C(O[[email protected]]1CN(C([[email protected]](C(C)(C)C)NC(COCCOCCOCCNC(C[[email protected]]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2)=O)=O)=O)[[email protected]](C(N[[email protected]](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)C1)COCCOCCOCCN=[N+]=[N-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (16.24 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8118 mL 4.0589 mL 8.1177 mL
5 mM 0.1624 mL 0.8118 mL 1.6235 mL
10 mM 0.0812 mL 0.4059 mL 0.8118 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 7.5 mg/mL (6.09 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 75 mg/mL (60.88 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (1.62 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.54%

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Keywords:

PROTAC BRD4 Degrader-5-CO-PEG3-N3PROTAC-linker Conjugate for PACADC CytotoxinPROTAC-linker for PROTAC-antibody ConjugateBRD4PROTACdegraderPEGInhibitorinhibitorinhibit

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Product Name:
PROTAC BRD4 Degrader-5-CO-PEG3-N3
Cat. No.:
HY-133736
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