GNE-987 GSH linker-1
Based on 1 Customer Validation
GNE-987 GSH linker-1, a PROTAC-linker Conjugate for PAC, comprises the chimeric BET degrader GNE-987 (HY-129937A) and disulfide-containing linker. GNE-987 GSH linker-1 remains inactive as a degrader until intracellular release of GNE-987 via disulfide reduction and linker self-immolation. GNE-987 GSH linker-1 can be used for the research of acute myeloid leukemia.
For research use only. We do not sell to patients.
- Purity: 98.66%
- CAS No.: 2417370-39-7
- Formula: C62H77F2N9O12S4
- Molecular Weight:1306.58
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
GNE-987 GSH linker-1 (compound 5) efficiently conjugates to CLL1-targeting and HER2-targeting monoclonal antibodies via its MTS disulfide moiety to form degrader-antibody conjugates with a DAR of ~6.0[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2417370-39-7
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Appearance Solid
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Molecular Weight 1306.58
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Formula C62H77F2N9O12S4
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Color White to off-white
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SMILES
O=C(CCCCCCCCCCNC(C1=C(CS(=O)(C)=O)C=C(C(N(C2=NC=C(F)C=C2F)C3)=C1)C4=CN(C)C(C5=C4C3=CN5)=O)=O)N[C@@H](C(C)(C)C)C(N6[C@H](C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)C[C@@H](OC(OCC(C)(C)SS(C)(=O)=O)=O)C6)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (76.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7654 mL | 3.8268 mL | 7.6536 mL | 19.1339 mL |
| 5 mM | 0.1531 mL | 0.7654 mL | 1.5307 mL | 3.8268 mL | |
| 10 mM | 0.0765 mL | 0.3827 mL | 0.7654 mL | 1.9134 mL | |
| 15 mM | 0.0510 mL | 0.2551 mL | 0.5102 mL | 1.2756 mL | |
| 20 mM | 0.0383 mL | 0.1913 mL | 0.3827 mL | 0.9567 mL | |
| 25 mM | 0.0306 mL | 0.1531 mL | 0.3061 mL | 0.7654 mL | |
| 30 mM | 0.0255 mL | 0.1276 mL | 0.2551 mL | 0.6378 mL | |
| 40 mM | 0.0191 mL | 0.0957 mL | 0.1913 mL | 0.4783 mL | |
| 50 mM | 0.0153 mL | 0.0765 mL | 0.1531 mL | 0.3827 mL | |
| 60 mM | 0.0128 mL | 0.0638 mL | 0.1276 mL | 0.3189 mL |
GNE-987 GSH linker-1 Related Classifications
HY-129938 Related Classifications
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