1. Antibody-drug Conjugate/ADC Related
    PROTAC
  2. PROTAC-linker Conjugate for PAC
  3. PROTAC BRD4 degrader for PAC-1

PROTAC BRD4 degrader for PAC-1 

Cat. No.: HY-129938 Purity: 98.02%
Handling Instructions

PROTAC BRD4 degrader for PAC-1 (compound 5), a PROTAC-linker Conjugate for PAC, comprises the chimeric BET degrader GNE-987 and disulfide-containing linker.

For research use only. We do not sell to patients.

PROTAC BRD4 degrader for PAC-1 Chemical Structure

PROTAC BRD4 degrader for PAC-1 Chemical Structure

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Description

PROTAC BRD4 degrader for PAC-1 (compound 5), a PROTAC-linker Conjugate for PAC, comprises the chimeric BET degrader GNE-987 and disulfide-containing linker[1].

Molecular Weight

1306.58

Formula

C₆₂H₇₇F₂N₉O₁₂S₄

SMILES

O=C(C1=C(CS(=O)(C)=O)C=C(C(N(C2=NC=C(F)C=C2F)C3)=C1)C4=CN(C)C(C5=C4C3=CN5)=O)NCCCCCCCCCCC(N[[email protected]@H](C(C)(C)C)C(N6[[email protected]](C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)C[[email protected]@H](OC(OCC(C)(C)SS(C)(=O)=O)=O)C6)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (76.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7654 mL 3.8268 mL 7.6536 mL
5 mM 0.1531 mL 0.7654 mL 1.5307 mL
10 mM 0.0765 mL 0.3827 mL 0.7654 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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  • Molarity Calculator

  • Dilution Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PROTAC BRD4 degrader for PAC-1PROTAC-linker Conjugate for PACPROTAC-linker for PROTAC-antibody ConjugateBRD4antibody-drugconjugatechimericproteindegraderdrugdeliveryInhibitorinhibitorinhibit

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Product name:
PROTAC BRD4 degrader for PAC-1
Cat. No.:
HY-129938
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