PROTAC BRD4 Degrader-24

Cat. No.: HY-129938 Purity: 99.61%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PROTAC BRD4 Degrader-24 (compound 5), a PROTAC-linker Conjugate for PAC, comprises the chimeric BET degrader GNE-987 and disulfide-containing linker.

For research use only. We do not sell to patients.

PROTAC BRD4 Degrader-24 Chemical Structure

CAS No. : 2417370-39-7

Size	Price	Stock	Quantity
1 mg	USD 1280	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 3200	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 4980	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

PROTAC BRD4 Degrader-24 (compound 5), a PROTAC-linker Conjugate for PAC, comprises the chimeric BET degrader GNE-987 and disulfide-containing linker^[1].

Molecular Weight

1306.58

Formula

C₆₂H₇₇F₂N₉O₁₂S₄

CAS No.

2417370-39-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(CS(=O)(C)=O)C=C(C(N(C2=NC=C(F)C=C2F)C3)=C1)C4=CN(C)C(C5=C4C3=CN5)=O)NCCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N6[C@H](C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)C[C@@H](OC(OCC(C)(C)SS(C)(=O)=O)=O)C6)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (76.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7654 mL	3.8268 mL	7.6536 mL
5 mM	0.1531 mL	0.7654 mL	1.5307 mL
10 mM	0.0765 mL	0.3827 mL	0.7654 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.61%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (263 KB) RP-HPLC (244 KB)

Handling Instructions (2659 KB)

References

[1]. Pillow TH, et al. Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity. ChemMedChem. 2019 Oct 31. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7654 mL	3.8268 mL	7.6536 mL	19.1339 mL
	5 mM	0.1531 mL	0.7654 mL	1.5307 mL	3.8268 mL
	10 mM	0.0765 mL	0.3827 mL	0.7654 mL	1.9134 mL
	15 mM	0.0510 mL	0.2551 mL	0.5102 mL	1.2756 mL
	20 mM	0.0383 mL	0.1913 mL	0.3827 mL	0.9567 mL
	25 mM	0.0306 mL	0.1531 mL	0.3061 mL	0.7654 mL
	30 mM	0.0255 mL	0.1276 mL	0.2551 mL	0.6378 mL
	40 mM	0.0191 mL	0.0957 mL	0.1913 mL	0.4783 mL
	50 mM	0.0153 mL	0.0765 mL	0.1531 mL	0.3827 mL
	60 mM	0.0128 mL	0.0638 mL	0.1276 mL	0.3189 mL