1. PROTAC
    Epigenetics
  2. PROTAC
    Epigenetic Reader Domain
  3. PROTAC BRD4 Degrader-5

PROTAC BRD4 Degrader-5 

Cat. No.: HY-133737 Purity: 99.51%
Handling Instructions

PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines.

For research use only. We do not sell to patients.

PROTAC BRD4 Degrader-5 Chemical Structure

PROTAC BRD4 Degrader-5 Chemical Structure

CAS No. : 2409538-70-9

Size Price Stock Quantity
10 mg USD 2200 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

PROTAC BRD4 Degrader-5 is a PROTAC-based BRD4 degrader. PROTAC BRD4 Degrader-5 can potent degrade BRD4 in HER2 positive and negative breast cancer cell lines[1].

IC50 & Target[1]

BRD4

 

In Vitro

PROTAC BRD4 Degrader-5 (Compound1; 5-100 nM; 4 hours; MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cells) treatment degrades BRD4 in cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cells
Concentration: 5 nM, 10 nM, 50 nM, 100 nM
Incubation Time: 4 hours
Result: Degradation of BRD4 in MCF-7, MDA-MB-231, SK-BR-3 and BT-474 cell.
Molecular Weight

1016.67

Formula

C₅₀H₆₂ClN₉O₈S₂

CAS No.

2409538-70-9

SMILES

O=C([[email protected]]1N(C([[email protected]](C(C)(C)C)NC(COCCOCCOCCNC(C[[email protected]]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2)=O)=O)=O)C[[email protected]](O)C1)N[[email protected]](C6=CC=C(C7=C(C)N=CS7)C=C6)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 145 mg/mL (142.62 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9836 mL 4.9180 mL 9.8360 mL
5 mM 0.1967 mL 0.9836 mL 1.9672 mL
10 mM 0.0984 mL 0.4918 mL 0.9836 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 7.25 mg/mL (7.13 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 7.25 mg/mL (7.13 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 7.25 mg/mL (7.13 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PROTAC BRD4 Degrader-5PROTACEpigenetic Reader DomainProteolysis-targeting chimeraVHLBRD4degraderPEGInhibitorinhibitorinhibit

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Product Name:
PROTAC BRD4 Degrader-5
Cat. No.:
HY-133737
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