Digitonin
Based on 21 publication(s) in Google Scholar
Digitonin, a glycoside obtained from Digitalis purpurea, could increase cell permeability by binding to cholesterol molecules and reduce tumor growth. Digitonin is an natural detergent.
For research use only. We do not sell to patients.
- Purity: 51.30%
- CAS No.: 11024-24-1
- Formula: C56H92O29
- Molecular Weight:1229.31
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Digitonin
More- Cell Res. 2022 Dec;32(12):1086-1104. [Abstract]
- Nat Commun. 2024 Mar 15;15(1):2371. [Abstract]
- Nat Commun. 2021 May 18;12(1):2915. [Abstract]
- Autophagy. 2022 Nov;18(11):2636-2655. [Abstract]
- Adv Sci (Weinh). 2026 Mar 12:e22572. [Abstract]
- Adv Sci (Weinh). 2025 Oct 30:e09933. [Abstract]
- J Biomed Sci. 2024 May 13;31(1):50. [Abstract]
- ISME J. 2023 Dec;17(12):2426-2440. [Abstract]
- Dev Cell. 2024 Jul 3:S1534-5807(24)00385-X. [Abstract]
- EMBO J. 2024 Dec;43(24):6383-6409. [Abstract]
- Food Front. 2025 Nov 20.
- Cell Rep. 2025 Oct 8;44(10):116421. [Abstract]
- Cell Rep. 2024 Jun 11;43(6):114358. [Abstract]
- Cell Rep. 2023 Jul 14;42(7):112798. [Abstract]
- Anal Chem. 2025 Aug 27. [Abstract]
- J Cell Biol. 2025 Mar 3;224(3):e202306101. [Abstract]
- JCI Insight. 2022 Feb 22;7(4):e149626. [Abstract]
- Int Immunopharmacol. 2025 Apr 16:155:114673. [Abstract]
- Viruses. 2022 Apr 21;14(5):861. [Abstract]
- Thromb J. 2025 Mar 18;23(1):26. [Abstract]
- SSRN. 2025 Aug 14.
Customer Validation & Images
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IF
Biological Activity
Digitonin, a detergent that increases cell permeability by binding to cholesterol molecules in the cell membrane, can increase cisplatin accumulation and reduce tumour growth in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 11024-24-1
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Appearance Solid
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Molecular Weight 1229.31
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Formula C56H92O29
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Color Off-white to light yellow
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SMILES
C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]34CC[C@@H](C)CO4)([H])[C@@H](O)[C@@]1([H])[C@@](CC[C@]5([H])[C@@]6(C[C@@H](O)[C@H](O[C@]([C@@H]([C@@H](O)[C@H]7O[C@@](O[C@H](CO)[C@@H](O)[C@@H]8O[C@@](OC[C@@H](O)[C@@H]9O)([H])[C@@H]9O)([H])[C@@H]8O[C@@](O[C@H](CO)[C@H](O)[C@@H]%10O[C@]([C@@H]([C@@H](O)[C@@H]%11O)O)([H])O[C@@H]%11CO)([H])[C@@H]%10O)O)([H])O[C@@H]7CO)C5)C)([H])[C@]6([H])CC2
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (21)
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Journal Impact Factor
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Most Recent
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Cell Res
Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity. [Abstract]2022 Dec;32(12):1086-1104. PMID: 36280710 -
Nat Commun
2024 Mar 15;15(1):2371. PMID: 38490996
Digitonin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Mar 15;15(1):2371. [Abstract]
Digitonin (25 mg/mL; 5 min). The white arrowheads indicate DsRed+ signals. Scale bar, 10 μm. The immunofluorescent staining images of HA-TANGO6-FLAG and TANGO6.
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Nat Commun
Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome. [Abstract]2021 May 18;12(1):2915. PMID: 34006824 -
Autophagy
ATF3 -activated accelerating effect of LINC00941/lncIAPF on fibroblast-to-myofibroblast differentiation by blocking autophagy depending on ELAVL1/HuR in pulmonary fibrosis. [Abstract]2022 Nov;18(11):2636-2655. PMID: 35427207 -
Adv Sci (Weinh)
2026 Mar 12:e22572. PMID: 41816968 -
Adv Sci (Weinh)
A Novel FGFR3-Targeting Antibody-Drug Conjugate Induces Tumor Cell Apoptosis through the cGAS-STING Pathway in Bladder Cancer. [Abstract]2025 Oct 30:e09933. PMID: 41168906 -
J Biomed Sci
A G-quadruplex-binding platinum complex induces cancer mitochondrial dysfunction through dual-targeting mitochondrial and nuclear G4 enriched genome. [Abstract]2024 May 13;31(1):50. PMID: 38741159 -
ISME J
Ginsenoside Rg3 enriches SCFA-producing commensal bacteria to confer protection against enteric viral infection via the cGAS-STING-type I IFN axis. [Abstract]2023 Dec;17(12):2426-2440. PMID: 37950067 -
Dev Cell
GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development. [Abstract]2024 Jul 3:S1534-5807(24)00385-X. PMID: 38981469 -
EMBO J
Rab2A-mediated Golgi-lipid droplet interactions support very-low-density lipoprotein secretion in hepatocytes. [Abstract]2024 Dec;43(24):6383-6409. PMID: 39496977 -
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Cell Rep
Mycobacterium bovis induces macrophage mitochondrial release of hexokinase 2 to enhance intracellular survival. [Abstract]2025 Oct 8;44(10):116421. PMID: 41066237 -
Cell Rep
Deciphering ER stress-unfolded protein response relationship by visualizing unfolded proteins in the ER. [Abstract]2024 Jun 11;43(6):114358. PMID: 38865243 -
Cell Rep
Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer. [Abstract]2023 Jul 14;42(7):112798. PMID: 37453063 -
Anal Chem
Probe-Encapsulated and Cell-Membrane-Anchored DNA Nanotoolboxes Enable In Situ Imaging of Extracellular Biochemical Components in Complex Biological Media. [Abstract]2025 Aug 27. PMID: 40866356 -
J Cell Biol
SARS-CoV-2 NSP3/4 control formation of replication organelle and recruitment of RNA polymerase NSP12. [Abstract]2025 Mar 3;224(3):e202306101. PMID: 39737877 -
JCI Insight
Mutations in OSBPL2 cause hearing loss associated with primary cilia defects via sonic hedgehog signaling. [Abstract]2022 Feb 22;7(4):e149626. PMID: 35041619 -
Int Immunopharmacol
mtDNA/RNA boosts radiation-induced abscopal effect via M1 macrophage polarization-promoted IFN-β-dependent inflammatory response. [Abstract]2025 Apr 16:155:114673. PMID: 40245773 -
Viruses
2022 Apr 21;14(5):861. PMID: 35632604 -
Thromb J
Oroxylin A reverses SHP-2 oxidative inactivation in GPVI signaling to suppress platelet activation and thrombus formation. [Abstract]2025 Mar 18;23(1):26. PMID: 40102927 -
Solvent & Solubility
H2O : 100 mg/mL (81.35 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (584 KB)
- English - EN (584 KB)
- Français - FR (584 KB)
- Deutsch - DE (584 KB)
- Norwegian - NO (584 KB)
- Español - ES (584 KB)
- Swedish - SV (584 KB)
- Italian - IT (584 KB)
- Portuguese - PT (584 KB)
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Handling Instructions (2659 KB)
References
[1]. Lindnér PG, et al. Digitonin enhances the efficacy of carboplatin in liver tumour after intra-arterial administration. Cancer Chemother Pharmacol. 1997;40(5):444-8. [Content Brief]
[2]. Leendert van Dalsen, et al. In meso Crystallogenesis. Compatibility of the Lipid Cubic Phase With the Synthetic Digitonin Analogue, Glyco-Diosgenin. J Appl Crystallogr. 2020 Mar 25;53(Pt 2):530-535. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.8135 mL | 4.0673 mL | 8.1346 mL | 20.3366 mL |
| 5 mM | 0.1627 mL | 0.8135 mL | 1.6269 mL | 4.0673 mL | |
| 10 mM | 0.0813 mL | 0.4067 mL | 0.8135 mL | 2.0337 mL | |
| 15 mM | 0.0542 mL | 0.2712 mL | 0.5423 mL | 1.3558 mL | |
| 20 mM | 0.0407 mL | 0.2034 mL | 0.4067 mL | 1.0168 mL | |
| 25 mM | 0.0325 mL | 0.1627 mL | 0.3254 mL | 0.8135 mL | |
| 30 mM | 0.0271 mL | 0.1356 mL | 0.2712 mL | 0.6779 mL | |
| 40 mM | 0.0203 mL | 0.1017 mL | 0.2034 mL | 0.5084 mL | |
| 50 mM | 0.0163 mL | 0.0813 mL | 0.1627 mL | 0.4067 mL | |
| 60 mM | 0.0136 mL | 0.0678 mL | 0.1356 mL | 0.3389 mL | |
| 80 mM | 0.0102 mL | 0.0508 mL | 0.1017 mL | 0.2542 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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