2. Natural Products
  3. Disease Research Fields Plants
  4. Scrophulariaceae Cancer
  5. Digitalis purpurea Linn.
  6. Digitonin

Digitonin, a glycoside obtained from Digitalis purpurea, could increase cell permeability by binding to cholesterol molecules and reduce tumor growth. Digitonin is an natural detergent.

For research use only. We do not sell to patients.

CAS No. : 11024-24-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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Based on 21 publication(s) in Google Scholar

Digitonin Related Antibodies

Top Publications Citing Use of Products

    Digitonin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Mar 15;15(1):2371.  [Abstract]

    Digitonin (25 mg/mL; 5 min). The white arrowheads indicate DsRed+ signals. Scale bar, 10 μm. The immunofluorescent staining images of HA-TANGO6-FLAG and TANGO6.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Digitonin, a glycoside obtained from Digitalis purpurea, could increase cell permeability by binding to cholesterol molecules and reduce tumor growth[1]. Digitonin is an natural detergent[2].

    In Vitro

    Digitonin, a detergent that increases cell permeability by binding to cholesterol molecules in the cell membrane, can increase cisplatin accumulation and reduce tumour growth in vitro[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Digitonin Related Antibodies
    In Vivo

    In the liver parenchyma the concentrations are of the same magnitude. Measured with the 133Xe-clearance technique, Digitonin does not alter the tumor blood flow. Digitonin enhances the tumor-growth retarding effect of CBDCA given intra-aterially at 5 mg/kg but not at 25 mg/kg[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    1229.31

    Formula

    C56H92O29
    CAS No.
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]34CC[C@@H](C)CO4)([H])[C@@H](O)[C@@]1([H])[C@@](CC[C@]5([H])[C@@]6(C[C@@H](O)[C@H](O[C@]([C@@H]([C@@H](O)[C@H]7O[C@@](O[C@H](CO)[C@@H](O)[C@@H]8O[C@@](OC[C@@H](O)[C@@H]9O)([H])[C@@H]9O)([H])[C@@H]8O[C@@](O[C@H](CO)[C@H](O)[C@@H]%10O[C@]([C@@H]([C@@H](O)[C@@H]%11O)O)([H])O[C@@H]%11CO)([H])[C@@H]%10O)O)([H])O[C@@H]7CO)C5)C)([H])[C@]6([H])CC2
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (81.35 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.8135 mL 4.0673 mL 8.1346 mL
    5 mM 0.1627 mL 0.8135 mL 1.6269 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 51.30%

    SDS (584 KB)

    COA (255 KB) HNMR (308 KB) LCMS (93 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 0.8135 mL 4.0673 mL 8.1346 mL 20.3366 mL
    5 mM 0.1627 mL 0.8135 mL 1.6269 mL 4.0673 mL
    10 mM 0.0813 mL 0.4067 mL 0.8135 mL 2.0337 mL
    15 mM 0.0542 mL 0.2712 mL 0.5423 mL 1.3558 mL
    20 mM 0.0407 mL 0.2034 mL 0.4067 mL 1.0168 mL
    25 mM 0.0325 mL 0.1627 mL 0.3254 mL 0.8135 mL
    30 mM 0.0271 mL 0.1356 mL 0.2712 mL 0.6779 mL
    40 mM 0.0203 mL 0.1017 mL 0.2034 mL 0.5084 mL
    50 mM 0.0163 mL 0.0813 mL 0.1627 mL 0.4067 mL
    60 mM 0.0136 mL 0.0678 mL 0.1356 mL 0.3389 mL
    80 mM 0.0102 mL 0.0508 mL 0.1017 mL 0.2542 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Digitonin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Digitonin11024-24-1OthersmilddetergentcellpermeabilitycholesterolmoleculesInhibitorinhibitorinhibit

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