2411422-49-4
Chemical Structure
(S,R,S)-AHPC-Me-C6-NH2
- CAS No.: 2411422-49-4
- Formula:C30H45N5O4S
- Molecular Weight:571.77
IUPAC Name: (2S,4R)-1-((S)-2-(7-aminoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
InChIKey: UGZLQBJANUBKTH-BOALBMDWSA-N
SMILES: NCCCCCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O
Biological Activity:
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(S,R,S)-AHPC-Me-C6-NH2 | 99.81% | (S,R,S)-AHPC-Me-C6-NH2 is a VHL E3 ubiquitin ligase ligand-linker conjugate structurally modified based on VHL ligand 2 (HY-112078). (S,R,S)-AHPC-Me-C6-NH2 can be used for the synthesis of PROTACs. |
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- [1]. Haibing Zhou, et al. Oseltamivir PROTAC compound, preparation method thereof and application thereof in anti-influenza virus drugs. Patent CN112592331A.
- [2]. Bondeson DP, et al. Systematic profiling of conditional degron tag technologies for target validation studies. Nat Commun. 2022;13(1):5495. Published 2022 Sep 20. [Content Brief]
Keywords