1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugates
  3. Lenalidomide-C5-NH2 hydrochloride

Lenalidomide-C5-NH2 hydrochloride 

Cat. No.: HY-122725B Purity: 98.44%
COA Handling Instructions

Lenalidomide-C5-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader.

For research use only. We do not sell to patients.

Lenalidomide-C5-NH2 hydrochloride Chemical Structure

Lenalidomide-C5-NH2 hydrochloride Chemical Structure

CAS No. : 2595367-27-2

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Solid + Solvent
10 mM * 1 mL in DMSO
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500 mg USD 950 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Lenalidomide-C5-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader[1][2].

IC50 & Target

Cereblon

 

Molecular Weight

365.85

Formula

C18H24ClN3O3

CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C1C(C=CC=C2CCCCCN)=C2CN1C3C(NC(CC3)=O)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (136.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7334 mL 13.6668 mL 27.3336 mL
5 mM 0.5467 mL 2.7334 mL 5.4667 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.44%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7334 mL 13.6668 mL 27.3336 mL 68.3340 mL
5 mM 0.5467 mL 2.7334 mL 5.4667 mL 13.6668 mL
10 mM 0.2733 mL 1.3667 mL 2.7334 mL 6.8334 mL
15 mM 0.1822 mL 0.9111 mL 1.8222 mL 4.5556 mL
20 mM 0.1367 mL 0.6833 mL 1.3667 mL 3.4167 mL
25 mM 0.1093 mL 0.5467 mL 1.0933 mL 2.7334 mL
30 mM 0.0911 mL 0.4556 mL 0.9111 mL 2.2778 mL
40 mM 0.0683 mL 0.3417 mL 0.6833 mL 1.7084 mL
50 mM 0.0547 mL 0.2733 mL 0.5467 mL 1.3667 mL
60 mM 0.0456 mL 0.2278 mL 0.4556 mL 1.1389 mL
80 mM 0.0342 mL 0.1708 mL 0.3417 mL 0.8542 mL
100 mM 0.0273 mL 0.1367 mL 0.2733 mL 0.6833 mL
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Lenalidomide-C5-NH2 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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