2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Lenalidomide-C5-NH2 hydrochloride

Lenalidomide-C5-NH2 hydrochloride 

Cat. No.: HY-122725B Purity: 98.44%
COA Handling Instructions

Lenalidomide-C5-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader.

For research use only. We do not sell to patients.

Lenalidomide-C5-NH2 hydrochloride Chemical Structure

Lenalidomide-C5-NH2 hydrochloride Chemical Structure

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Solution
10 mM * 1 mL in DMSO USD 440 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 400 In-stock
Estimated Time of Arrival: December 31
500 mg USD 950 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Lenalidomide-C5-NH2 hydrochloride:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1

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Description

Lenalidomide-C5-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader[1][2].

IC50 & Target

Cereblon

 

Molecular Weight

365.85

Appearance

Solid

Formula

C18H24ClN3O3
SMILES

O=C1C(C=CC=C2CCCCCN)=C2CN1C3C(NC(CC3)=O)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Lenalidomide-C5-NH2E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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