2595367-27-2
2595367-27-2
Chemical Structure
Lenalidomide-C5-NH2 hydrochloride
- CAS No.: 2595367-27-2
- Formula:C18H24ClN3O3
- Molecular Weight:365.85
IUPAC Name: 3-(4-(5-aminopentyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
InChIKey: MDQAJUCZXLGNMH-UHFFFAOYSA-N
SMILES: O=C1C(C=CC=C2CCCCCN)=C2CN1C3C(NC(CC3)=O)=O.Cl
Biological Activity: Lenalidomide-C5-NH2 hydrochloride is an E3 ligase ligand-linker conjugate. Lenalidomide-C5-NH2 hydrochloride can be coupled to a target protein ligand via a linker to form a PROTAC molecule—such as a PROTAC degrader for MDM2[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Lenalidomide-C5-NH2 hydrochloride | 99.28% | Lenalidomide-C5-NH2 hydrochloride is an E3 ligase ligand-linker conjugate. Lenalidomide-C5-NH2 hydrochloride can be coupled to a target protein ligand via a linker to form a PROTAC molecule—such as a PROTAC degrader for MDM2. | ||||||||||||||||||||
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References
- [1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. [Content Brief]
- [2]. Yangbing Li, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466. [Content Brief]
Keywords
