2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Lenalidomide-C5-NH2 TFA

Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader.

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Lenalidomide-C5-NH2 TFA Chemical Structure

Lenalidomide-C5-NH2 TFA Chemical Structure

CAS No. : 2550398-71-3

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Lenalidomide-C5-NH2 TFA Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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Description

Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs, such as MDM2 PROTAC degrader[1][2].

IC50 & Target

Cereblon

 

Molecular Weight

443.42

Formula

C20H24F3N3O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(N(CC1=C2C=CC=C1CCCCCN)C2=O)CC3)NC3=O.OC(C(F)(F)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation
References
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Lenalidomide-C5-NH2 TFA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lenalidomide-C5-NH22550398-71-3E3 Ligase Ligand-Linker ConjugatesLenalidomideCereblonCRBNPROTACMDM2 PROTAC degraderInhibitorinhibitorinhibit

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