2550398-71-3
2550398-71-3
Chemical Structure
Lenalidomide-C5-NH2 TFA
- CAS No.: 2550398-71-3
- Formula:C20H24F3N3O5
- Molecular Weight:443.42
IUPAC Name: 3-(4-(5-aminopentyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione 2,2,2-trifluoroacetate
InChIKey: XTHUZCHGWIIXLO-UHFFFAOYSA-N
SMILES: O=C(C(N(CC1=C2C=CC=C1CCCCCN)C2=O)CC3)NC3=O.OC(C(F)(F)F)=O
Biological Activity: Lenalidomide-C5-NH2 TFA is an E3 ligase ligand-linker conjugate. Lenalidomide-C5-NH2 TFA can be coupled to a target protein ligand via a linker to form a PROTAC molecule—such as a PROTAC degrader for MDM2[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Lenalidomide-C5-NH2 TFA | 98.94% | Lenalidomide-C5-NH2 TFA is an E3 ligase ligand-linker conjugate. Lenalidomide-C5-NH2 TFA can be coupled to a target protein ligand via a linker to form a PROTAC molecule—such as a PROTAC degrader for MDM2. | ||||||||||||||||||||
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References
- [1]. Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018;61(2):462-481. [Content Brief]
- [2]. Li Y, Yang J, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019;62(2):448-466. [Content Brief]
Keywords
