1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Lenalidomide-C5-NH2

Lenalidomide-C5-NH2 (Synonyms: Cereblon Ligand-Linker Conjugates 19; E3 ligase Ligand-Linker Conjugates 31)

Cat. No.: HY-122725 Purity: 98.94%
Handling Instructions

Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs.

For research use only. We do not sell to patients.

Lenalidomide-C5-NH2 Chemical Structure

Lenalidomide-C5-NH2 Chemical Structure

CAS No. : 2093388-45-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 440 In-stock
Estimated Time of Arrival: December 31
100 mg USD 400 In-stock
Estimated Time of Arrival: December 31
500 mg USD 950 In-stock
Estimated Time of Arrival: December 31
1 g USD 1600 In-stock
Estimated Time of Arrival: December 31
2 g USD 2600 Get quote
5 g   Get quote  
10 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Lenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs[1].

IC50 & Target[1]

Cereblon

 

Molecular Weight

329.39

Formula

C₁₈H₂₃N₃O₃

CAS No.

2093388-45-3

SMILES

O=C(C(N(CC1=C2C=CC=C1CCCCCN)C2=O)CC3)NC3=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (151.80 mM; Need ultrasonic)

DMSO : 5 mg/mL (15.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0359 mL 15.1796 mL 30.3591 mL
5 mM 0.6072 mL 3.0359 mL 6.0718 mL
10 mM 0.3036 mL 1.5180 mL 3.0359 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.5 mg/mL (1.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.5 mg/mL (1.52 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.5 mg/mL (1.52 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Lenalidomide-C5-NH2
Cat. No.:
HY-122725
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