2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Lenalidomide-C4-NH2 hydrochloride

Lenalidomide-C4-NH2 hydrochloride  (Synonyms: Cereblon ligand 1 hydrochloride; E3 ligase Ligand-Linker Conjugates 32 hydrochloride)

Cat. No.: HY-115446A Purity: 98.85%
COA Handling Instructions

Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively.

For research use only. We do not sell to patients.

Lenalidomide-C4-NH2 hydrochloride Chemical Structure

Lenalidomide-C4-NH2 hydrochloride Chemical Structure

Size Price Stock Quantity
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
500 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1

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Description

Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively[1].

IC50 & Target

Cereblon

 

Molecular Weight

351.83

Appearance

Solid

Formula

C17H22ClN3O3
SMILES

O=C(C(N(CC1=C2C=CC=C1CCCCN)C2=O)CC3)NC3=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 130 mg/mL (369.50 mM; Need ultrasonic)

H2O : 100 mg/mL (284.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8423 mL 14.2114 mL 28.4228 mL
5 mM 0.5685 mL 2.8423 mL 5.6846 mL
10 mM 0.2842 mL 1.4211 mL 2.8423 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (142.11 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (6.17 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (6.17 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Lenalidomide-C4-NH2Cereblon ligand 1E3 ligase Ligand-Linker Conjugates 32Cereblon ligand1Cereblon ligand-1E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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Lenalidomide-C4-NH2 hydrochloride
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