1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Lenalidomide-C4-NH2 hydrochloride

Lenalidomide-C4-NH2 hydrochloride (Synonyms: Cereblon ligand 1 hydrochloride; E3 ligase Ligand-Linker Conjugates 32 hydrochloride)

Cat. No.: HY-115446A Purity: 98.24%
Handling Instructions

Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively.

For research use only. We do not sell to patients.

Lenalidomide-C4-NH2 hydrochloride Chemical Structure

Lenalidomide-C4-NH2 hydrochloride Chemical Structure

Size Price Stock Quantity
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
500 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively[1].

IC50 & Target[1]

Cereblon

 

Molecular Weight

351.83

Formula

C₁₇H₂₂ClN₃O₃

SMILES

O=C(C(N(CC1=C2C=CC=C1CCCCN)C2=O)CC3)NC3=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 130 mg/mL (369.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8423 mL 14.2114 mL 28.4228 mL
5 mM 0.5685 mL 2.8423 mL 5.6846 mL
10 mM 0.2842 mL 1.4211 mL 2.8423 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (6.17 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (6.17 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Lenalidomide-C4-NH2 hydrochloride
Cat. No.:
HY-115446A
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