2435715-90-3
Chemical Structure
Lenalidomide-C4-NH2 hydrochloride
Synonym(s): Cereblon ligand 1 hydrochloride; E3 ligase Ligand-Linker Conjugates 32 hydrochloride
- CAS No.: 2435715-90-3
- Formula:C17H22ClN3O3
- Molecular Weight:351.83
IUPAC Name: 3-(4-(4-aminobutyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
InChIKey: QPGHLNCBGNJWKG-UHFFFAOYSA-N
SMILES: O=C(C(N(CC1=C2C=CC=C1CCCCN)C2=O)CC3)NC3=O.Cl
Biological Activity: Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively[1].
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Lenalidomide-C4-NH2 hydrochloride | 95.84% | Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC50s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively. | ||||||||||||||||||||
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