Lenalidomide-4-aminomethyl hydrochloride
Based on 1 Customer Validation
Lenalidomide-4-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC
For research use only. We do not sell to patients.
- Purity: 97.39%
- CAS No.: 444289-05-8
- Formula: C14H16ClN3O3
- Molecular Weight:309.75
-
Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 444289-05-8
-
Appearance Solid
-
Molecular Weight 309.75
-
Formula C14H16ClN3O3
-
Color White to off-white
-
SMILES
O=C(C(N(CC1=C2C=CC=C1CN)C2=O)CC3)NC3=O.[H]Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 25 mg/mL (80.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. [Content Brief]
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2284 mL | 16.1421 mL | 32.2841 mL | 80.7103 mL |
| 5 mM | 0.6457 mL | 3.2284 mL | 6.4568 mL | 16.1421 mL | |
| 10 mM | 0.3228 mL | 1.6142 mL | 3.2284 mL | 8.0710 mL | |
| 15 mM | 0.2152 mL | 1.0761 mL | 2.1523 mL | 5.3807 mL | |
| 20 mM | 0.1614 mL | 0.8071 mL | 1.6142 mL | 4.0355 mL | |
| 25 mM | 0.1291 mL | 0.6457 mL | 1.2914 mL | 3.2284 mL | |
| 30 mM | 0.1076 mL | 0.5381 mL | 1.0761 mL | 2.6903 mL | |
| 40 mM | 0.0807 mL | 0.4036 mL | 0.8071 mL | 2.0178 mL | |
| 50 mM | 0.0646 mL | 0.3228 mL | 0.6457 mL | 1.6142 mL | |
| 60 mM | 0.0538 mL | 0.2690 mL | 0.5381 mL | 1.3452 mL | |
| 80 mM | 0.0404 mL | 0.2018 mL | 0.4036 mL | 1.0089 mL |
Lenalidomide-4-aminomethyl hydrochloride Related Classifications
HY-138882A Related Classifications
Powered by Bioz