Lenalidomide-4-aminomethyl hydrochloride

Name: Lenalidomide-4-aminomethyl hydrochloride
Brand: MedChemExpress
SKU: HY-138882A
Rating: 4.5 (1 reviews)

Cat. No.: HY-138882A Pureza: 97.39%: Ficha de datos
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Lenalidomide-4-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC

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Lenalidomide-4-aminomethyl hydrochloride Estructura química

No. CAS : 444289-05-8

Tamaño	Stock	Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

Other Forms of Lenalidomide-4-aminomethyl hydrochloride:

Lenalidomide-4-aminomethyl Obtener un presupuesto

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas Ligands for E3 Ligase:

Ver todas las isoformas

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

IC₅₀ & Target

Cereblon

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

309.75

Fòrmula

C₁₄H₁₆ClN₃O₃

No. CAS

444289-05-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(C(N(CC1=C2C=CC=C1CN)C2=O)CC3)NC3=O.[H]Cl

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : 25 mg/mL (80.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2284 mL	16.1420 mL	32.2841 mL
5 mM	0.6457 mL	3.2284 mL	6.4568 mL
10 mM	0.3228 mL	1.6142 mL	3.2284 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 97.39%

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Ficha de datos (273 KB) SDS (393 KB)

COA (251 KB) HNMR (293 KB) LCMS (324 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. [Content Brief]

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2284 mL	16.1421 mL	32.2841 mL	80.7103 mL
	5 mM	0.6457 mL	3.2284 mL	6.4568 mL	16.1421 mL
	10 mM	0.3228 mL	1.6142 mL	3.2284 mL	8.0710 mL
	15 mM	0.2152 mL	1.0761 mL	2.1523 mL	5.3807 mL
	20 mM	0.1614 mL	0.8071 mL	1.6142 mL	4.0355 mL
	25 mM	0.1291 mL	0.6457 mL	1.2914 mL	3.2284 mL
	30 mM	0.1076 mL	0.5381 mL	1.0761 mL	2.6903 mL
	40 mM	0.0807 mL	0.4036 mL	0.8071 mL	2.0178 mL
	50 mM	0.0646 mL	0.3228 mL	0.6457 mL	1.6142 mL
	60 mM	0.0538 mL	0.2690 mL	0.5381 mL	1.3452 mL
	80 mM	0.0404 mL	0.2018 mL	0.4036 mL	1.0089 mL